glycerophosphodiester phosphodiesterase

E coli enzyme; acts on variety of substrates to give glycerol-3-phosphate plus an alcohol, such as ethanolamine, choline, glycerol or glycerophosphoglycerol

Also Known As:

GDE1 protein, mouse; GDE3 protein, human; GDE4 protein, human; GDPD2 protein, human; GDPD5 protein, mouse; GPDE-phosphodiesterase; Gdpd2 protein, mouse; GlpQ enzyme; GpdQ enzyme; Osteoblast differentiation promoting factor protein, human; glycerophosphodiester phosphodiesterase 2; glycerophosphodiester phosphodiesterase domain containing 2 protein, human; glycerophosphodiester phosphodiesterase domain containing 2 protein, mouse; glycerophosphodiesterase; glycerophosphosphoryl diester phosphodiesterase

Networked: 32 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Esterases: 1574
      - Phosphoric Diester Hydrolases: 2391
        glycerophosphodiester phosphodiesterase: 32

Experts

1.	Kawabata, Hiroki: 3 articles (10/2018 - 05/2017)
2.	Ohnishi, Makoto: 3 articles (10/2018 - 05/2017)
3.	Sato, Kozue: 3 articles (10/2018 - 05/2017)
4.	Hengstler, Jan G: 3 articles (01/2014 - 05/2012)
5.	Lesjak, Michaela S: 3 articles (01/2014 - 05/2012)
6.	Marchan, Rosemarie: 3 articles (01/2014 - 05/2012)
7.	Stewart, Joanna D: 3 articles (01/2014 - 05/2012)
8.	Schwan, Tom G: 3 articles (08/2009 - 02/2003)
9.	Giepmans, Ben N G: 2 articles (12/2016 - 10/2016)
10.	Jalink, Kees: 2 articles (12/2016 - 10/2016)

Related Diseases

1.	Otitis Media 10/01/2008 - "Haemophilus influenzae outer membrane protein D (PD) is a glycerophosphodiester phosphodiesterase (GlpQ) activity-possessing virulence factor and a promising vaccine antigen, providing 35.3% efficacy against acute otitis media caused by nontypeable H. "
2.	Relapsing Fever 01/01/2022 - "In our study, a total of 1609 ticks (745 nymphs, 358 females and 506 males) collected from different localities in eastern Slovakia were analysed using a polymerase chain reaction targeting a gene encoding glycerophosphodiester phosphodiesterase (glpQ), which is specific to the Borrelia species in the relapsing fever group. " 05/01/2006 - "Detection of relapsing fever in human blood samples from Israel using PCR targeting the glycerophosphodiester phosphodiesterase (GlpQ) gene." 02/01/2003 - "Borrelia hermsii, a tick-borne relapsing-fever spirochete, contains orthologs to glpQ and glpT, genes that encode glycerophosphodiester phosphodiesterase (GlpQ) and glycerol-3-phosphate transporter (GlpT), respectively. " 10/01/2000 - "The glpQ gene, encoding glycerophosphodiester phosphodiesterase, from these isolates was sequenced and compared with the glpQ sequences obtained from other relapsing-fever spirochetes. " 10/01/2000 - "Serodiagnosis of Louse-Borne relapsing fever with glycerophosphodiester phosphodiesterase (GlpQ) from Borrelia recurrentis."
3.	Neoplasm Metastasis (Metastasis) 05/01/2018 - "The purpose of this study is to determine whether the gene glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) contributes to CRC cell metastasis and 5-Fu resistance. " 05/22/2012 - "Choline-releasing glycerophosphodiesterase EDI3 drives tumor cell migration and metastasis."
4.	Lyme Disease (Disease, Lyme) 10/01/2018 - "In this study, we examined 459 cases of clinically suspected Lyme disease (LD group), and found twelve cases that were seropositive for the glycerophosphodiester phosphodiesterase (GlpQ) antigen derived from B. " 10/01/2016 - "Species identification was verified by PCR of the outer surface protein A (ospA) gene for Lyme Disease Borrelia spp. and by PCR of the glycerophosphodiester phosphodiesterase (glpQ) gene for relapsing fever Borrelia spp. Lyme Borrelia spp. were found in 15/71 (21.13%) of the ticks evaluated and included B. "
5.	Neoplasms (Cancer) 09/01/2012 - "Here, we demonstrate for the first time that the GPC-PDE encoded by glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) is associated with breast cancer malignancy. " 12/15/2012 - "Choline-releasing glycerophosphodiesterase EDI3 links the tumor metabolome to signaling network activities." 01/01/2020 - "Glycerophosphodiester phosphodiesterase 1 (GDE1) acts as a potential tumor suppressor and is a novel therapeutic target for non-mucin-producing colon adenocarcinoma." 01/01/2014 - "Endometrial carcinoma differential 3 (EDI3) was the first member of the glycerophosphodiesterase (GDE) protein family shown to be associated with cancer. " 05/22/2012 - "Choline-releasing glycerophosphodiesterase EDI3 drives tumor cell migration and metastasis."

Related Drugs and Biologics

1.	Antigens
2.	Virulence Factors (Pathogenicity Factors)
3.	Vaccines
4.	Membrane Proteins (Integral Membrane Proteins)
5.	Fluorouracil (Carac)
6.	Choline (Choline Chloride)
7.	Proteins (Proteins, Gene)
8.	Phospholipids (Phosphatides)
9.	Glypicans
10.	Phosphatidylcholines (Phosphatidylcholine)

Related Therapies and Procedures

1.	Therapeutics