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alanylproline

RN given refers to all (L)-isomer

Also Known As:

Ala-Pro; L-alanyl-L-proline

Networked: 36 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Dipeptides: 945
      - alanylproline: 36

Experts

1.	Hinou, Hiroshi: 2 articles (01/2016 - 01/2013)
2.	Nishimura, Shin-Ichiro: 2 articles (01/2016 - 01/2013)
3.	Ohyabu, Naoki: 2 articles (01/2016 - 01/2013)
4.	Akcay, Berkay: 1 article (06/2022)
5.	Arici, Aydin: 1 article (06/2022)
6.	Bahceci, Mustafa: 1 article (06/2022)
7.	Basar, Murat: 1 article (06/2022)
8.	Boynukalin, Kubra: 1 article (06/2022)
9.	Olcay, I Orcun: 1 article (06/2022)
10.	Ozpinar, Aysel: 1 article (06/2022)

Related Diseases

1.	Essential Hypertension 09/01/1983 - "The antihypertensive efficacy of N-[(S)-1-(ethoxycarbonyl)-3-phenyl-propyl]-L-alanyl-L-proline (enalapril maleate) was evaluated in a randomized, double-blind trial in 23 patients with mild low-renin essential hypertension ranging in age from 32 to 70 yr (20 were black and 3 were white). "
2.	Neoplasms (Cancer) 09/25/2023 - "To assess the therapeutic effects of Laxiflorin B, we synthesized a Laxiflorin B-ALA pro-drug and delivered it by intraperitoneal injection (10 mg/kg) into a 4T1 orthotopic tumor mouse model. " 02/19/2002 - "Tumor cell growth was inhibited dose-dependently for the conjugates carrying Ala-Val and Gly-Pro linkers, whereas significant inhibitory effect was abolished for the conjugate carrying Ala-Pro linker, indicating that cytotoxic effect can be controlled by specificity of antibody and composition of linker peptide. " 01/01/2017 - "This study presents the synthesis of the novel protected O-glycosylated amino acid derivatives 1 and 2, containing βGalNAc-SerOBn and βGalNAc-ThrOBn units, respectively, as mimetics of the natural Tn antigen (αGalNAc-Ser/Thr), along with the solid-phase assembly of the glycopeptides NHAcSer-Ala-Pro-Asp-Thr[αGalNAc]-Arg-Pro-Ala-Pro-Gly-BSA (3-BSA) and NHAcSer-Ala-Pro-Asp-Thr[βGalNAc]-Arg-Pro-Ala-Pro-Gly-BSA (4-BSA), bearing αGalNAc-Thr or βGalNAc-Thr units, respectively, as mimetics of MUC1 tumor mucin glycoproteins. " 01/15/2013 - "Systematic nuclear magnetic resonance (NMR) study revealed that sialylation of the MUC1 tandem repeating glycopeptide, Pro-Pro-Ala-His-Gly-Val-Thr-Ser-Ala-Pro-Asp-Thr-Arg-Pro-Ala-Pro-Gly-Ser-Thr-Ala with core 2-type O-glycans at five potential glycosylation sites, afforded a specific conformational change at one of the most important cancer-relevant epitopes (Pro-Asp-Thr-Arg). "
3.	Sudden Infant Death (SID) 10/11/2020 - "Similar to the trend of AID of CP, the OCM addition increased the AID and standardized ileal digestibility (SID) of Ile, Thr, and Cys in CSM diet, but decreased the AID and SID of Ile, Phe, Thr, Val, Ala, Pro, Ser, and Tyr in WSM diet. " 01/01/2015 - "The FSBMB diet had higher SIDs in most AAs compared with the FSBMA diet (P < 0.05), and higher SIDs of Lys, Ala, Pro, Ser, and Tyr compared with PSBM diet (P < 0.05). " 07/02/2019 - "In Exp. 2, significant differences (P < 0.05) were observed in the SID of Arg, His, Phe, Ala, Pro, Cys, and Tyr. "
4.	Anemia 02/01/2001 - "Hb Mont Saint Aignan [beta128(H6)Ala-->Pro]: a new unstable variant leading to chronic microcytic anemia." 05/01/2005 - "The homozygous state for Hb Crete [beta129 (H7) Ala-->Pro] is associated with a complex phenotype including erythrocytosis and functional anemia." 10/04/1988 - "Hemoglobin Brockton [beta 138 (H16) Ala----Pro] is an unstable variant associated with a mild anemia. "
5.	Prolidase Deficiency 01/01/1988 - "Prolidase activity in serum from normal subjects and the mother of two patients was readily detected without adding Mn2+ to the assay, and the activity was increased by addition of Mn2+ to the assay or preincubation with Mn2+. However, the activity in serum from patients with prolidase deficiency against gly-pro, leu-pro and val-pro could not be detected irrespective of Mn2+ conditions and activity against met-pro, ala-pro and phe-pro also showed a marked reduction compared to controls. " 05/18/1990 - "The quasi-molecular ions [M + H]+ of various iminodipeptides were also observed in the urine samples of patients with prolidase deficiency, and Gly-Pro, Ala-Pro, Val-Pro, Leu-Pro, Ile-Pro, Ser-Pro, Thr-Pro, Glu-Pro, Asp-Pro, His-Pro, Lys-Pro, Pro-Pro and Tyr-Pro as iminodipeptides containing proline with C-terminal residue and Glu-Hyp, Pro-Hyp, Ile-Hyp and Gly-Hyp as iminodipeptides containing hydroxyproline with C-terminal residue were identified in the urine of patients with prolidase deficiency."

Related Drugs and Biologics

1.	Renin
2.	Enalapril
3.	Antihypertensive Agents (Antihypertensives)
4.	arginylproline
5.	Glycopeptides
6.	alanyl-prolyl-glycine
7.	Glycoproteins (Glycoprotein)
8.	Amino Acids
9.	Polysaccharides (Glycans)
10.	Mucins

Related Therapies and Procedures

1.	Intraperitoneal Injections