alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase

incorporates N-acetyglucosamine as the third branch of complex N-glycosyl-oligosaccharide of hen oviduct

Also Known As:

GlcNAc-transferase IV; GnT-IV; N-acetylglucosaminyltransferase IV; UDP-GlcNAc-GnGn(GlcNAc to Man alpha1-3)beta 4-N-acetylglucosaminyltransferase IV; UDP-N-acetylglucosamine alpha-1,3-mannoside beta-1,4-N-acetylglucosaminyltransferase

Networked: 16 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Glycosyltransferases: 784
      - N-Acetylhexosaminyltransferases
        N-Acetylglucosaminyltransferases: 23
        alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase: 16

Experts

1.	Takeuchi, Makoto: 2 articles (11/2006 - 01/2004)
2.	Kajiyama, Hiroaki: 1 article (01/2022)
3.	Niimi, Kaoru: 1 article (01/2022)
4.	Nishiko, Yuki: 1 article (01/2022)
5.	Nishino, Kimihiro: 1 article (01/2022)
6.	Oda, Yukari: 1 article (01/2022)
7.	Shibata, Mayu: 1 article (01/2022)
8.	Watanabe, Eri: 1 article (01/2022)
9.	Yamamoto, Eiko: 1 article (01/2022)
10.	Balog, Crina I A: 1 article (01/2018)

Related Diseases

1.	Choriocarcinoma 10/08/1999 - "This supposition was confirmed by molecular biological study of GnT-IV in placenta and choriocarcinoma cell lines. " 11/01/1988 - "The altered glycosylation of hCG is brought about by the ectopic expression of N-acetylglucosaminyltransferase IV. With use of this altered glycosylation, a novel method useful for the diagnosis of choriocarcinoma was established." 01/01/2004 - "To confirm this, we measured the N-acetylglucosaminyltransferase (GnT)-IV activity and hCG productivity in three choriocarcinoma cell lines, and selected JEG-3 cells. " 08/15/1999 - "GnT-IV activities in choriocarcinoma cell lines were increased from 16- to 66-fold and GnT-III activity was increased from 15- to 25-fold as compared with those in human placentae, whereas other enzyme activities were not increased significantly. " 01/01/2022 - "Cell surface membrane LAMP-2, which is glycosylated by GnT-IV, contributes to the malignancy of choriocarcinoma by promoting cell adhesion with the ECM via abundant N-glycans."
2.	Neoplasms (Cancer) 06/10/2005 - "The gene encoding for mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetyl-glucosaminyl-transferase (GnT-IV) became significantly upregulated in primary/metastatic tumor pairs (p < 0.001). " 08/15/1999 - "Among the two GnT-IV genes found in human tissues only GnT-IVa gene was strongly expressed in the cancer cells: from three to seven times as much as in the normal tissue, whereas that of GnT-IVb remained constant. " 01/01/2018 - "While active, it inhibits the action of other GlcNAc transferases such as GnT-IV and GnT-V. Moreover, GnT-III is considered as an inhibitor of the metastatic potential of cancer cells both in vitro and in vivo. " 01/01/2015 - "In addition to these enzymes, GnT-IV and GnT-IX (GnT-Vb) will be also discussed in relation to cancer. " 11/01/2006 - "Two human GnT-IV isozymes (GnT-IVa and GnT-IVb) had been identified, which exhibit different expression profiles among human tissues and cancer cell lines. "
3.	Pancreatic Neoplasms (Pancreatic Cancer) 11/17/2000 - "The primary structure was found to be significantly similar to human GnT IV-homologue, the gene for which was cloned from the deleted region in pancreatic cancer, and to human and bovine GnT IVs. " 10/01/1998 - "The activities of three N-acetylglucosaminyltransferases (GnT III, GnT IV and GnT V) were determined in 10 samples of pancreatic carcinoma (PCa) and compared with those in 9 samples of normal pancreatic tissue (NP). " 01/01/1999 - "A novel human gene determining a polypeptide product of 478 residues with an estimated molecular mass of 55 kDa, which has significant homology and structural similarity to Bos UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase (GnT-IV), was cloned from the commonly deleted region in pancreatic cancer at 12q21. "
4.	Lung Neoplasms (Lung Cancer) 03/05/2013 - "Two glycan nodes provided novel evidence for altered ST6Gal-I and GnT-IV glycotransferase activities in lung cancer patients. "
5.	Hepatocellular Carcinoma (Hepatoma) 09/14/1990 - "A relatively higher activity for GnT-V is found in small intestine, serum and hepatoma as compared to that of GnT-IV. Some kinetic properties of these enzymes in crude extracts were also determined."

Related Drugs and Biologics

1.	Enzymes
2.	alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase
3.	Transferases
4.	Polysaccharides (Glycans)
5.	Sugars
6.	Lysosomal Membrane Proteins
7.	Complex Mixtures
8.	N-Acetylglucosaminyltransferases
9.	Uridine Diphosphate (UDP)
10.	Proteins (Proteins, Gene)