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phenalen-1-one

fossil fuel combustion product

Also Known As:

perinaphthenone; phenalenone

Networked: 9 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Phenalenes: 1
        phenalen-1-one: 9
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Phenalenes: 1
    - phenalen-1-one: 9

Experts

1.	Beharry, Andrew A: 1 article (08/2021)
2.	Kailass, Karishma: 1 article (08/2021)
3.	Kaye, Esther G: 1 article (08/2021)
4.	Sadovski, Oleg: 1 article (08/2021)
5.	Li, Helin: 1 article (04/2021)
6.	Li, Ying: 1 article (04/2021)
7.	Liu, Zhaojun: 1 article (04/2021)
8.	Nie, Yongzhi: 1 article (04/2021)
9.	Shi, Lingling: 1 article (04/2021)
10.	Wang, Hongyu: 1 article (04/2021)

Related Diseases

1.	Triple Negative Breast Neoplasms 07/05/2023 - "In this study, we report a new redshift phenalenone derivative, 6-amino-5-iodo-1H-phenalen-1-one (SDU Red [SR]), as a lysosome-targeting photosensitizer for triple-negative breast cancer therapy. "
2.	Neoplasms (Cancer) 11/01/2018 - "Phenalenone-photodynamic therapy induces apoptosis on human tumor cells mediated by caspase-8 and p38-MAPK activation." 08/12/2021 - "Overall, OE19 opens up the possibility of employing phenalenone-based photosensitizers as theranostic agents for photodynamic cancer therapy." 10/01/1996 - "Phenalenone was mutagenic in Salmonella in the presence of rat liver postmitochondrial supernatant (PMS) at a minimum detectable mutagen concentration (MDMC) of 12 micrograms/ml, but was not mutagenic in the absence of PMS at concentrations up to 100 micrograms/ ml. Phenalenone was not significantly mutagenic in either human cell line after 28 hr treatment, although mutant fractions were increased by nearly fivefold in h1A1v2 cells (at the tk locus) exposed at 30 micrograms/ml. However, after 72 hr treatment, phenalenone was mutagenic at the hprt locus in h1A1v2 cells with an MDMC of 3 micrograms/ml. Phenalenone was also tumorigenic in male BLU:Ha mice with a lung tumor incidence of 33% 6 months after injection with 4.2 mg phenalenone, the highest dose tested. " 07/05/2023 - "Phenalenone is a type II photosensitizer with a high singlet oxygen quantum yield; however, its short UV absorption wavelength hinders its application in cancer imaging and in vivo photodynamic therapy. "
3.	Photosensitivity Disorders (Photodermatitis) 01/25/2018 - "Phenalenone (PN) derivatives are involved in plant defense strategies, producing molecular singlet oxygen in a photosensitization process. " 03/01/2005 - "The persistence of the model photosensitizer suggests that the photosensitization by perinaphthenone occurs either by triplet-energy transfer or an electron transfer followed by rapid regeneration of the sensitizer. " 03/01/2005 - "Significant photosensitization was observed in solutions of Suwanee River fulvic acid and Mississippi River water, as well as for the model photosensitization compounds 3'-methoxyacetophenone, 2-acetonaphthone and perinaphthenone. "
4.	Typhoid Fever (Typhoid) 01/01/2018 - "These were docked with the 19 marketed anti-typhoid drugs along with two phenalenone-furanone derivatives, 15 non-related drugs which showed 70% similarity to phenalenone and furanone derivatives and other analogous small molecules. "
5.	Trypanosomiasis 06/15/2010 - "A set of derivatives encompassing structural modifications on the privileged phenalenone scaffold were assessed for their antiparasitic activities against the most clinically relevant forms of trypanosomiasis and leishmaniasis. "

Related Drugs and Biologics

1.	Photosensitizing Agents (Photosensitizers)
2.	Singlet Oxygen
3.	Caspase 8 (Caspase-8)
4.	Mutagens
5.	Hypoxanthine Phosphoribosyltransferase (Hypoxanthine Guanine Phosphoribosyltransferase)
6.	Antiparasitic Agents (Antiparasitics)
7.	1-phenyl-3,3-dimethyltriazene (PDT)
8.	fulvic acid

Related Therapies and Procedures

1.	Therapeutics
2.	Photochemotherapy (Photodynamic Therapy)
3.	Precision Medicine