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5'-methylthioinosine

MH METHYLTHIOINOSINE refers to 6-methylthioinosine

Also Known As:

5'-deoxy-5'-methylthioinosine; 5-DMTI

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Carcinoma (Carcinomatosis) 06/10/1984 - "We report that one subline of a heterogeneous human colon carcinoma, DLD-1 Clone D, only forms methylthioribose-1-P from methylthioadenosine or 5'-deoxy-5'-methylthioinosine (methylthioinosine), a deaminated derivative of methylthioadenosine, whereas Clone A converts methylthioadenosine and methylthioinosine to methionine, as shown by growth studies in culture of Clone A and Clone D cells and radioactive studies utilizing [methyl-14C]methylthioadenosine or [methyl-14C]methylthioinosine in the presence of extracts of these cells lines. "
2.	T-Cell Leukemia (Leukemia, T Cell) 10/01/1983 - "CCRF-CEM T-cell leukemia cells, which lack 5'-deoxy-5'-methylthioadenosine phosphorylase, convert 5'-deoxy-5'-methylthioinosine (but not 5'-deoxy-5'-methylthioadenosine) to methionine; this conversion is blocked by purine nucleoside phosphorylase inhibitors. "
3.	Leukemia 10/01/1983 - "5'-Deoxy-5'-methylthioadenosine and 5'-deoxy-5'-methylthioinosine, which are metabolized to the methionine precursor, 5-methylthioribose-1-phosphate, by 5'-deoxy-5'-methylthioadenosine phosphorylase and purine nucleoside phosphorylase, respectively, can serve as sources of methionine for cultured HL-60 promyelocytic leukemia cells. "

Related Drugs and Biologics

1.	Methionine (L-Methionine)
2.	Methylthioinosine
3.	Purine-Nucleoside Phosphorylase
4.	5'-methylthioadenosine phosphorylase (methylthioadenosine nucleosidase)
5.	5'-methylthioadenosine