N- (7- (4- nitrobenzo- 2- oxa- 1,3- diazole))- 6- aminocaproyl sphingosine

fluorescent ceramide analog; structure given in first source

Also Known As:

6-N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)aminocaproylsphingosine; C6-NBD-Cer; C6-NBD-ceramide; NBD C6-Cer; NBD-ceramide; Hexanamide, N-(2-hydroxy-1-(hydroxymethyl)-3-heptadecenyl)-6-((7-nitro-4-benzofurazanyl)amino)-

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Afrin, Farjana: 1 article (08/2019)
2.	Barrott, Jared J: 1 article (08/2019)
3.	Fatema, Kaniz: 1 article (08/2019)
4.	Habashi, Yashar A: 1 article (08/2019)
5.	Meldrum, Trevor C: 1 article (08/2019)
6.	Pashikanti, Srinath: 1 article (08/2019)
7.	Pavek, Adriene: 1 article (08/2019)
8.	Stegelmeier, John L: 1 article (08/2019)
9.	Kaneko, Masayuki: 1 article (01/2010)
10.	Murayama, Toshihiko: 1 article (01/2010)

Related Diseases

1.	Farber Lipogranulomatosis 08/08/2003 - "Furthermore, when 12-(N-methyl-N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)) (NBD)-conjugated lauric acid and sphingosine were added to cultured lymphoblasts from a Farber disease patient in the presence of fumonisin B (1), the conversion to NBD-ceramide was reduced approximately 30% when compared with normal cells. "
2.	Neoplasms (Cancer) 08/31/2019 - "We used a commercially available NBD-ceramide to apply to human cancer cell lines in the presence or absence of a known SMS inhibitor, jaspine B. "
3.	Malaria 02/01/1994 - "(a) The induction of an extensive network of tubovesicular membranes by the malaria parasite Plasmodium falciparum in the cytoplasm of the mature erythrocyte, and its visualization with two ceramide analogues C5-DMB-ceramide and C6-NBD-ceramide. "
4.	Adenocarcinoma of Lung 01/01/2010 - "Also we found that 1) treatment of NBD-ceramide-labeled cells (human lung adenocarcinoma A549 cells and Chinese hamster ovary cells) with Na(3)VO(4) increased the amount of NBD-C1P formed within 30 min, 2) the treatment increased production of NBD-caproic acid, a counterpart of sphingosine, by ceramidase within 2 h, 3) expression of ceramide kinase enhanced the Na(3)VO(4)-induced formation of NBD-C1P, and tyrosine kinase inhibitors (herbimycin and genistein) decreased the response, 4) the production of NBD-caproic acid in A549 cells was inhibited by genistein, and 5) the responses for 2 h after Na(3)VO(4) treatment were accompanied by a decrease in the production of NBD-sphingomyelin, not a loss of NBD-ceramide. "

Related Drugs and Biologics

1.	Sphingosine
2.	Ceramidases
3.	Genistein
4.	Ceramides
5.	Tyrosine Kinase Inhibitors
6.	pachastrissamine
7.	ceramide kinase
8.	fumonisin B1
9.	N- 4- nitrobenzo- 2- oxa- 1,3- diazoleaminocaproyl sphingosylphosphorylcholine
10.	hexanoic acid (hexanoate)