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4-fluoroestradiol
RN given refers to unlabeled (17 beta)-isomer
Also Known As:
4-fluoro-17 beta-estradiol; 4-fluoroestradiol, (17beta)-isomer, 18F-labeled
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Polycyclic Compounds: 6
Fused-Ring Compounds
Steroids: 70059
Estranes
Estrenes
Estradiol: 14115
4-fluoroestradiol: 3
Hormones, Hormone Substitutes, and Hormone Antagonists
Hormones: 80400
Gonadal Hormones: 716
Gonadal Steroid Hormones: 7657
Estradiol Congeners: 358
Estradiol: 14115
4-fluoroestradiol: 3
Related Diseases
1.
Neoplasms (Cancer)
06/01/1994 - "
17 beta-Estradiol is known to induce kidney tumors in male Syrian hamsters when administered chronically, whereas 4-fluoroestradiol does so only after an extended induction period and 2-fluoroestradiol is not carcinogenic; both fluorinated analogs are hormonally active.
"
04/01/1993 - "
In male Syrian hamsters, an animal model for estradiol-induced carcinogenesis, 2-fluoroestradiol was not carcinogenic, whereas 4-fluoroestradiol induced kidney tumors after a prolonged latency period, compared with estradiol (100% tumor incidence), when the compounds were administered to hamsters in hormonally equipotent doses.
"
04/01/1993 - "
To examine this proposed mechanism of tumor induction by estrogens, we investigated the conversion of 2- and 4-fluoroestradiol to catechol metabolites by kidney and liver microsomes of hamsters and the further conversion to methyl ethers by catechol-O-methyltransferase, and we compared the values with those obtained with nonfluorinated estrogens as substrates.
"
2.
Carcinogenesis
04/01/1993 - "
In male Syrian hamsters, an animal model for estradiol-induced carcinogenesis, 2-fluoroestradiol was not carcinogenic, whereas 4-fluoroestradiol induced kidney tumors after a prolonged latency period, compared with estradiol (100% tumor incidence), when the compounds were administered to hamsters in hormonally equipotent doses.
"
04/01/1993 - "
Microsomal hydroxylation of 2- and 4-fluoroestradiol to catechol metabolites and their conversion to methyl ethers: catechol estrogens as possible mediators of hormonal carcinogenesis.
"
3.
Carcinoma (Carcinomatosis)
03/01/1983 - "
4-Fluoroestradiol, also a potent estrogen, did induce renal clear-cell carcinoma in this animal model, but more slowly than estradiol.
"
Related Drugs and Biologics
1.
Estradiol (Delestrogen)
2.
Estrogens (Estrogen)
3.
2-fluoroestradiol
4.
Methyl Ethers
5.
Catechol O-Methyltransferase (Methyltransferase, Catechol)
6.
Catechol Estrogens
7.
catechol (pyrocatechol)