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ropivacaine (Naropin)

Subscribe to New Research on ropivacaine

amide local anesthetic with characteristics similar to bupivacaine; from Apothekernes Laboratorium, Oslo, Norway; RN given refers to (S)-isomer; RN for parent cpd without isomeric designation not available 2/89

Also Known As:

Naropin; 1-propyl-2',6'-pipecoloxylidide; AL 381; AL-381; Astra brand of ropivacaine monohydrochloride; AstraZeneca brand of ropivacaine monohydrochloride; LEA 103; LEA-103; Naropeine; ropivacaine hydrochloride; ropivacaine monohydrochloride; ropivacaine monohydrochloride, (S)-isomer

Networked: 1045 relevant articles (145 outcomes, 217 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Amides: 231
  - ropivacaine: 1045

Experts

1.	Casati, A: 14 articles (07/2007 - 01/2000)
2.	Ilfeld, Brian M: 13 articles (01/2015 - 06/2002)
3.	Fanelli, G: 10 articles (07/2007 - 01/2000)
4.	Borgeat, Alain: 9 articles (11/2014 - 02/2002)
5.	Loland, Vanessa J: 7 articles (01/2015 - 11/2008)
6.	Mariano, Edward R: 6 articles (11/2014 - 03/2007)
7.	Fredrickson, Michael J: 6 articles (09/2012 - 11/2009)
8.	Casati, Andrea: 6 articles (11/2004 - 04/2002)
9.	Fanelli, Guido: 5 articles (08/2015 - 04/2002)
10.	Kehlet, H: 5 articles (05/2015 - 11/2008)

Related Diseases

1.	Pain (Aches) 05/01/2009 - "Continuous ropivacaine perineural infusion (n = 15) produced a statistically and clinically significant reduction in average pain (median [10th-90th percentile]) on POD 1 compared with saline infusion (n = 15) after initial ropivacaine bolus (0.0 [0.0-5.0] versus 3.0 [0.0-6.0], respectively; P < 0.001). " 04/01/2006 - "The pain assessments upon movement of the operated joint were significantly greater after 24 hours in the group receiving a single dose of ropivacaine to block the sciatic nerve. " 11/01/2004 - "We found a statistically significant improvement in pain scores at 2 and 4 hours in the group allocated to receive a patent drain and ropivacaine. " 11/01/2010 - "Continuous supraclavicular BPB with 0.2% ropivacaine at 6 ml x hr(-1) is effective for the pain management after shoulder surgery and is not an excess dose." 03/04/2010 - "The continuous infusion of ropivacaine is effective in controlling pain for a wide variety of surgical procedures and reducing opioid adverse effects and dependency. "
2.	Postoperative Pain 09/07/2010 - "CFNA with ropivacaine 0.2% is more effective in controlling postoperative pain than CIA and CFNB is an effective regional component of a multimodal analgesic strategy after TKA." 01/01/2002 - "Ropivacaine 1 mg x ml(-1) showed less efficacy while the use of ropivacaine 3 mg x ml(-1) was associated with a higher incidence of motor block with minimal improvement in postoperative pain relief." 01/01/2014 - "Ropivacaine CWI is effective for postoperative pain management in a wide range of surgical procedures." 01/01/2014 - "We investigated the efficacy of combining local anaesthetic infiltration of ropivacaine with pulmonary recruitment manoeuvre on postoperative pain following diagnostic hysteroscopy and laparoscopy. " 07/01/2005 - "Ropivacaine flush almost eliminated the postoperative pain and discomfort. "
3.	Wounds and Injuries (Trauma) 09/10/2013 - "Surgical wound infusion with ropivacaine is safe and effective. " 03/01/2013 - "The aim of this prospective, randomized, double-blind, placebo controlled trial was to evaluate the safety and efficacy of continuous ropivacaine infusion of into the sternal wound. " 12/01/2012 - "This trial sought to determine the efficacy of ropivacaine wound infusion following laparoscopic colonic surgery. " 12/01/2010 - "The analgesic efficacy of continuous wound instillation with ropivacaine after open hepatic surgery." 09/01/2004 - "The postoperative analgesic efficacy of wound instillation with ropivacaine 0.1% versus ropivacaine 0.2%."
4.	Cataract (Cataracts) 06/01/1999 - "We conclude that 1% ropivacaine is a suitable agent for single injection peribulbar anaesthesia for cataract surgery." 03/01/2007 - "Deep-topical anaesthesia with ropivacaine or lidocaine was equally effective in providing anaesthesia with sufficient quality for cataract surgery." 12/01/2011 - "Cataract surgery complications: an in vitro model of toxic effects of ropivacaine and lidocaine." 06/01/2006 - "Levobupivacaine (0.5%) has better anaesthetic properties with respect to 0.75% ropivacaine and is well-suited for peribulbar block in cataract surgery." 06/01/2006 - "Efficacy and comparison of 0.5% levobupivacaine with 0.75% ropivacaine for peribulbar anaesthesia in cataract surgery."
5.	Hallux Valgus (Bunion) 09/01/2006 - "Eighty-three patients scheduled to undergo acromioplasty or hallux valgus surgery received an interscalene (n = 40) or popliteal (n = 43) peripheral nerve block with 30 ml ropivacaine, 0.5%. " 11/01/2012 - "Forty patients scheduled for ambulatory percutaneous hallux valgus repair were randomly assigned to two anesthesia and analgesia blocks: foot infiltration achieved by a mild foot block, or sciatic nerve block (30mL of 7.5% ropivacaine for each block). " 11/01/2010 - "Forty ambulatory patients who underwent chevron osteotomy for hallux valgus were randomized to receive perisciatic infusion of ropivacaine 2 mg/ml at a rate of either 5 ml/h (5 ml group) or 8 ml/h (8 ml group). " 11/01/2010 - "Perisciatic infusion of ropivacaine and analgesia after hallux valgus repair." 09/01/2004 - "In 60 patients receiving elective hallux valgus repair, we compared the efficacy of continuous popliteal sciatic nerve block produced with 0.2% ropivacaine (n = 20), 0.2% levobupivacaine (n = 20), or 0.125% levobupivacaine (n = 20) infused with a patient-controlled system starting 3 h after a 30-mL bolus of the 0.5% concentration of the study drug and for 48 h (baseline infusion rate, 6 mL/h; incremental dose, 2 mL; lockout time, 15 min; maximum incremental doses per hour, 3). "

Related Drugs and Biologics

1.	Bupivacaine (Bupivacaine Hydrochloride)
2.	Morphine (MS Contin)
3.	Lidocaine (Xylocaine)
4.	levobupivacaine (Chirocaine)
5.	Fentanyl (Sublimaze)
6.	Sufentanil (Sufenta)
7.	Clonidine (ST 155)
8.	Ketorolac
9.	Opioid Analgesics (Opioids)
10.	elastomeric

Related Therapies and Procedures

1.	Analgesia
2.	Catheters
3.	Epidural Analgesia
4.	Anesthesia
5.	Tonsillectomy