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HC toxin

maize host-specific toxin isolated from culture filtrates of Helminthosporium carbonum (cochliobolus)
Also Known As:
HC-toxin; Helminthosporium carbonum toxin; cyclo(2-amino-8-oxo-9,10-epoxydecanoic acid-prolyl-alanyl-alanine); cyclo(Aoe-Pro-Ala-Ala); Cyclic(L-alanyl-D-alanyl-eta-oxo-L-alpha-aminooxiraneoctanoyl-D-prolyl)
Networked: 22 relevant articles (2 outcomes, 2 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Chintamanani, Satya: 2 articles (10/2018 - 02/2008)
2. Johal, Gurmukh S: 2 articles (10/2018 - 02/2008)
3. Barooah, Madhumita: 2 articles (01/2014 - 09/2013)
4. Choudhury, Manabendra Dutta: 2 articles (01/2014 - 09/2013)
5. Dehury, Budheswar: 2 articles (01/2014 - 09/2013)
6. Modi, Mahendra Kumar: 2 articles (01/2014 - 09/2013)
7. Patra, Mahesh Chandra: 2 articles (01/2014 - 09/2013)
8. Sahu, Jagajjit: 2 articles (01/2014 - 09/2013)
9. Sen, Priyabrata: 2 articles (01/2014 - 09/2013)
10. Deubzer, Hedwig E: 2 articles (06/2008 - 04/2008)

Related Diseases

1. Neuroblastoma
2. Cholangiocarcinoma
3. Breast Neoplasms (Breast Cancer)
4. Infections
5. Neoplasms (Cancer)
04/15/2008 - "In conclusion, nanomolar doses of the HDACI HC-toxin cause a shift to a differentiated and benign phenotype of NB cells that is associated with an activation of the RB tumor suppressor network."
07/16/2021 - "Although each tumor displayed a unique compound sensitivity profile, Panobinostat, LAQ824, and HC toxin were broadly effective across most tumors. "
01/01/2016 - "Additionally, crystal structures of complexes with eight different inhibitors, including belinostat and panobinostat (currently used in cancer chemotherapy), the macrocyclic tetrapeptide HC toxin, and the HDAC6-specific inhibitor N-hydroxy-4-(2-((2-hydroxyethyl)(phenyl)amino)-2-oxoethyl)benzamide, revealed surprising new insight regarding changes in Zn(2+) coordination and isozyme-specific inhibition."
01/01/2008 - "Naturally occurring cyclic tetrapeptides (CTPs) such as tentoxin (Halloin et al., Plant Physiol 1970, 45, 310-314; Saad, Phytopathology 1970, 60, 415-418), ampicidin (Darkin-Rattray, Proc Natl Acad Sci USA 1996, 93, 13143-13147), HC-toxin (Walton, Proc Natl Acad Sci USA 1987, 84, 8444-8447), and trapoxin (Yoshida and Sugita, Jpn J Cancer Res 1992, 83, 324-328; Itazaki et al., J Antibiot (Tokyo) 1990, 43, 1524-1532) have a wide range of biological activity and potential use ranging from herbicides (Walton, Proc Natl Acad Sci USA 1987, 84, 8444-8447; Judson, J Agric Food Chem 1987, 35, 451-456) to therapeutics (Loiseau, Biopolymers 2003, 69, 363-385) for malaria (Darkin-Rattray, Proc Natl Acad Sci USA 1996, 93, 13143-13147) and cancer (Yoshida and Sugita, Jpn J Cancer Res 1992, 83, 324-328). "

Related Drugs and Biologics

1. Histone Deacetylase Inhibitors
2. trichostatin A (A 300)
3. Estrogen Receptors
4. Oxidoreductases (Dehydrogenase)
5. NADP (NADPH)
6. Histone Deacetylases (Histone Deacetylase)
7. Panobinostat
8. chlamydocin
9. Cytostatic Agents
10. Isoenzymes

Related Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)