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aptazapine

structure given in first source

Also Known As:

1,3,4,14b-tetrahydro-2-methyl-10H-pyrazino-(1,2-a)pyrrolo(2,1-c)(1,4)benzodiazepine; CGS 7525A; CGS-7525A; aptazapine maleate (1:1)

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzazepines: 5
      - Benzodiazepines: 8452
        aptazapine: 2

Related Diseases

1.	Mydriasis 01/01/1988 - "The order of potency for compounds fully antagonizing clonidine-induced mydriasis was MSD 26 greater than physostigmine = idazoxan greater than aptazapine greater than piperoxan greater than yohimbine greater than mianserin greater than tolazoline. "
2.	Cataplexy 06/01/1990 - "Yohimbine (1.5-96.0 micrograms/kg i.v.) and seven other selective and centrally acting alpha-2 adrenoceptor antagonists (rauwolscine: 1.5-96 micrograms/kg i.v.; atipemazole: 1.5-96 micrograms/kg i.v.; Wy-25309: 1.5-386 micrograms/kg i.v.; CGS-7525A: 1.5-386 micrograms/kg i.v.; idazoxan, 6-1536 micrograms/kg i.v.; piperoxan, 6-1536 micrograms/kg i.v.; and mianserin, 6-1536 micrograms/kg i.v.) significantly suppressed cataplexy. "

Related Drugs and Biologics

1.	Idazoxan
2.	Yohimbine (Yocon)
3.	Piperoxan
4.	Mianserin
5.	Tolazoline (Priscoline)
6.	Adrenergic Receptors (Adrenergic Receptor)
7.	Physostigmine
8.	Clonidine (ST 155)
9.	Wy 25309