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buciclovir

structure given in first source

Also Known As:

9-(3,4-dihydroxybutyl)guanine; DHBG; bucyclovir; 6H-Purin-6-one, 2-amino-9-(3,4-dihydroxybutyl)-1,9-dihydro-

Networked: 5 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purinones: 2
        Hypoxanthines: 1
        Guanine: 1793
        Acyclovir: 4814
        buciclovir: 5

Related Diseases

1.	Infections 02/01/1986 - "The efficacy of the anti-herpesvirus drug buciclovir [(R)-9-(3,4-dihydroxybutyl)guanine] was investigated in guinea pigs and mice infected intravaginally with herpes simplex virus type 2. Topical treatment initiated early after infection was efficacious, in contrast to topical treatment delayed 24 h or more. " 06/01/1988 - "The herpesvirus DNA polymerase inhibitor foscarnet, applied topically, and the anti-herpesvirus guanosine analogue buciclovir, given orally, decreased virus replication and disease development in primary skin infections of mice caused by herpes simplex virus type 1 (HSV-1). " 05/15/1988 - "Despite incorporation of buciclovir into RNA, and the presence of buciclovir-triphosphate from the time of infection onwards, no effect was observed on the synthesis of the beta proteins ICP-6 and ICP-8. "
2.	Herpes Genitalis (Genital Herpes) 02/01/1986 - "Efficacy of the acyclic guanosine analog buciclovir [(R)-9-(3,4-dihydroxybutyl)guanine] in experimental genital herpes."
3.	Herpesviridae Infections (Herpesvirus Infection) 02/01/1986 - "Our results suggest that buciclovir has only a limited effect against herpesvirus infections once the virus is present in the nervous systems of infected animals."
4.	Herpes Simplex 05/01/1986 - "The effects of the acyclic guanosine analogs acyclovir (ACV) and (R)-9-(3,4-dihydroxybutyl)guanine (bucyclovir, BCV) on the deoxyribonucleoside triphosphate (dNTP) pools of herpes simplex type 1 (HSV-1)-infected African green monkey kidney (GMK) and human embryonic lung fibroblast (HL) cells were investigated. "
5.	Iron Deficiencies 02/01/1968 - "Under conditions of iron deficiency, strains of Bacillus subtilis produced 2,3-dihydroxybenzoic acid (DHB), 2,3-dihydroxybenzolyglycine (DHBG), or both of these compounds. "

Related Drugs and Biologics

1.	Guanosine
2.	Guanine
3.	Nucleic Acid Synthesis Inhibitors
4.	Foscarnet
5.	RNA (Ribonucleic Acid)
6.	Proteins (Proteins, Gene)
7.	Acyclovir (Aciclovir)
8.	bucyclovir triphosphate
9.	2,3-dihydroxybenzoic acid
10.	triphosphoric acid (triphosphate)

Related Therapies and Procedures

1.	Treatment Delay