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21- hydroxy- 9beta,10alpha- pregna- 5,7- diene- 3- ol- 20- one

metabolite of dydrogesterone isolated from urine of rhesus monkey

Also Known As:

metabolite M; Pregna-5,7-dien-20-one, 3,21-dihydroxy-, (3beta,9beta,10alpha)-

Networked: 8 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Pregnanes: 9
      - Pregnadienes
        Dydrogesterone: 223
        21-hydroxy-9beta,10alpha-pregna-5,7-diene-3-ol-20-one: 8

Experts

1.	Cajka, Tomas: 1 article (01/2020)
2.	DiDonato, Joseph A: 1 article (01/2020)
3.	Fiehn, Oliver: 1 article (01/2020)
4.	Fischbach, Michael A: 1 article (01/2020)
5.	Funabashi, Masanori: 1 article (01/2020)
6.	Gupta, Nilaksh: 1 article (01/2020)
7.	Hazen, Stanley L: 1 article (01/2020)
8.	Li, Lin: 1 article (01/2020)
9.	Mohan, Maradumane L: 1 article (01/2020)
10.	Naga Prasad, Sathyamangla Venkata: 1 article (01/2020)

Related Diseases

1.	Pericarditis 05/01/2015 - "Termination of Atrial Flutter and Fibrillation by K201's Metabolite M-II: Studies in the Canine Sterile Pericarditis Model."
2.	Atrial Flutter (Flutter, Atrial) 05/01/2015 - "Termination of Atrial Flutter and Fibrillation by K201's Metabolite M-II: Studies in the Canine Sterile Pericarditis Model."
3.	Drug-Related Side Effects and Adverse Reactions 11/01/2017 - "Subjects with adverse drug reactions had lower concentrations of trazodone suggesting its metabolite (m-chlorophenylpiperazine) could be responsible for these effects."
4.	Stroke (Strokes) 01/01/2020 - "Using untargeted metabolomics (n = 1,162 subjects), the plasma metabolite (m/z = 265.1188) phenylacetylglutamine (PAGln) was discovered and then shown in an independent cohort (n = 4,000 subjects) to be associated with cardiovascular disease (CVD) and incident major adverse cardiovascular events (myocardial infarction, stroke, or death). "
5.	Opioid-Related Disorders (Opiate Addiction) 05/01/1991 - "The antidepressant trazodone and its main metabolite, m-CPP, having an antiserotoninergic and serotoninergic activity respectively, were studied in an acute dependence model in mice, to establish whether 5-hydroxytryptaminergic systems are involved in the manifestations of acute opiate dependence and in its development. "

Related Drugs and Biologics

1.	Trazodone (Trittico)
2.	6-chloro-2-(1-piperazinyl)pyrazine (CPP)
3.	Glucuronides
4.	Interleukin-10 (Interleukin 10)
5.	Tacrolimus (Prograf)
6.	Biomarkers (Surrogate Marker)
7.	Antidepressive Agents (Antidepressants)
8.	xanthurenic acid
9.	phenylacetylglutamine