5,7-dimethoxycoumarin

07/20/2022 - "In this study, we investigated its attenuating effect of citropten isolated from Citrus aurantifolia extract on DSS-induced colitis through the modulation of the activity of T cells and intestinal epithelial cells. "
12/01/2023 - "These findings provide novel insights into the anti-colitis effect of citropten, which may be a promising drug candidate for treatment of IBD."
12/01/2023 - "Citropten alleviates acute and recurrent colitis via blockage of NF-κB and JAK/STAT3 pathways."
07/20/2022 - "Ameliorative Effect of Citropten Isolated from Citrusaurantifolia Peel Extract as a Modulator of T Cell and Intestinal Epithelial Cell Activity in DSS-Induced Colitis."
12/01/2023 - "Mechanism investigations revealed that citropten significantly inhibited the activation of NF-κB and JAK/STAT3 signaling pathways, thus leading to decreased inflammation, Th17 cells and alleviative colitis. "

12/01/2023 - "In this study, we demonstrated that citropten could alleviate dextran sulfate sodium (DSS)-induced acute and recurrent colitis in mice, with significant improvement in body weight loss, disease activity index, shortened colon length and histological changes. "
07/20/2022 - "We elucidated that the oral administration of citropten alleviates the colonic inflammation and activity of effector T cells in DSS-induced colitis by measuring changes in body weight, histological scoring from H&E-stained sections, mRNA levels of pro-inflammatory cytokines and the phosphorylation level of the MAPK signaling pathway."

01/01/2023 - "5,7-Dimethoxycoumarin ameliorates vincristine induced neuropathic pain: potential role of 5HT3 receptors and monoamines."

06/01/2009 - "In this study, the processes of differentiation and melanogenesis induced by 5,7-dimethoxycoumarin in murine (B16) and human (A375) melanoma cells were investigated. "
02/01/2008 - "In the present study we investigated the antiproliferative activity of 5,7-dimethoxycoumarin on the murine B16 and human A375 melanoma cell lines. "
02/01/2008 - "Cell cycle arrest and differentiation induction by 5,7-dimethoxycoumarin in melanoma cell lines."
11/01/2014 - "The aim of the study was to investigate whether the valproic acid and 5,7-dimethoxycoumarin have an antiproliferative activity against A2058 human melanoma cell line. "
11/01/2014 - "Antiproliferative effect of valproic acid and 5,7-dimethoxycoumarin against A2058 human melanoma cells."

04/15/2011 - "These obtained results clearly indicate that bergapten and citropten are strong inhibitors of IL-8 expression and could be proposed for further studies to verify possible anti-inflammatory properties to reduce lung inflammation in CF patients."