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gusperimus

synthesized by chemical modification of spergualin; in combination with cyclosporin A prevents diabetes in predisposed NOD mice; structure given in first source; RN given refers to (-)-isomer trihydrochloride

Also Known As:

1-amino-19-guanidino-11-hydroxy-4,9,12-triazanonadecane-10,13-dione; 15-deoxyspergualin; NKT-01; deoxyspergualin; gusperimus trihydrochloride; gusperimus, (+-)-isomer; Heptanamide, 7-((aminoiminomethyl)amino)-N-(2-((4-((3-aminopropyl)amino)butyl)amino)-1-hydroxy-2-oxoethyl)-

Networked: 122 relevant articles (10 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 58
- Amidines: 11
  - Guanidines: 20
    - gusperimus: 122

Experts

1.	Nemoto, Kyuichi: 3 articles (01/2011 - 01/2006)
2.	Birck, Rainer: 3 articles (01/2006 - 02/2003)
3.	Schmitt, Wilhelm H: 2 articles (01/2011 - 06/2005)
4.	Heinzel, Peter A: 2 articles (01/2011 - 06/2005)
5.	Saiga, Kan: 2 articles (07/2010 - 05/2002)
6.	Jayne, David R W: 2 articles (03/2010 - 09/2008)
7.	Flossmann, Oliver: 2 articles (03/2010 - 09/2008)
8.	Nemoto, K: 2 articles (07/2009 - 12/2006)
9.	Hellmich, B: 2 articles (07/2009 - 12/2005)
10.	van der Woude, Fokko J: 2 articles (01/2006 - 06/2005)

Related Diseases

1.	Wegener Granulomatosis (Wegener's Granulomatosis) 06/01/2005 - "Prolonged treatment of refractory Wegener's granulomatosis with 15-deoxyspergualin: an open study in seven patients." 03/01/2010 - "Long-term treatment of relapsing Wegener's granulomatosis with 15-deoxyspergualin." 07/01/2009 - "Deoxyspergualin in relapsing and refractory Wegener's granulomatosis." 03/01/2009 - "Polyamine compound deoxyspergualin (DSG) is a potent immunosuppressive agent that has been applied clinically for protecting graft rejection and treatment of Wegener's granulomatosis. " 12/01/2006 - "15-Deoxyspergualin (DSG) is an alternative treatment modality for Wegener's granulomatosis (WG) patients refractory to conventional treatment. "
2.	Autoimmune Diseases (Autoimmune Disease) 09/01/1995 - "Deoxyspergualin (DSG) is a potent immunosuppressive agent that is currently undergoing clinical trials for treatment of transplant rejection, preventive of human anti-mouse Ab response, and blocking autoimmune disease progression. " 06/23/1993 - "Preclinical studies with 15-deoxyspergualin in various animal models for autoimmune diseases." 01/01/1993 - "Immunosuppressive therapy of organ-specific nephritic autoimmune diseases with 15-deoxyspergualin." 09/01/1991 - "15-Deoxyspergualin (15-DOS) has a curative effect on the development of SLE-like autoimmune disease in MRL/1 mice." 09/01/1988 - "Biological activities of deoxyspergualin in autoimmune disease mice."
3.	Coronary Artery Disease (Coronary Atherosclerosis) 02/01/1999 - "Inhibitory effect of 15-deoxyspergualin on coronary arteriosclerosis in the transplanted heart." 09/01/1994 - "Effects of cyclosporine and 15-deoxyspergualin on coronary arteriosclerosis after heart transplantation in the rat." 09/01/1994 - "We concluded that 15-Deoxyspergualin is superior to cyclosporine in preventing graft coronary arteriosclerosis after heart transplantation." 09/01/1994 - "The purpose of this study was to evaluate the effects of 15-Deoxyspergualin on graft coronary arteriosclerosis after heterotopic heart transplantation in a rat model and compare the effects to those of cyclosporine treatment. " 10/01/1993 - "The purpose of this study is to evaluate the effects of Cyclosporine (CsA), FK-506 (FK) and 15-Deoxyspergualin (DOS) on coronary arteriosclerosis after rat heart transplantation. "
4.	Glomerulonephritis 11/01/1999 - "Immunosuppressive effect of deoxyspergualin in proliferative glomerulonephritis." 01/01/1999 - "[Effects of deoxyspergualin on proliferative glomerulonephritis]." 05/01/1995 - "It has previously been shown that the immunosuppressive drug deoxyspergualin can inhibit renal injury in experimental glomerulonephritis. " 05/01/1993 - "Suppression of experimental crescentic glomerulonephritis by deoxyspergualin." 10/01/2005 - "Safety of 15-deoxyspergualin in the treatment of glomerulonephritis associated with active systemic lupus erythematosus."
5.	Graft vs Host Disease (Graft-Versus-Host Disease) 02/01/1988 - "The efficacy of 15-deoxyspergualin (15-DS) was tested in two models of experimental graft versus host disease (GvHD) in mice. " 09/01/2000 - "Reduced levels of Hsp70 result in a therapeutic effect of 15-deoxyspergualin on acute graft-versus-host disease in (DA x LEW)F1 rats." 11/18/1999 - "A series of new analogues of 15-deoxyspergualin (DSG), an immunosuppressive agent commercialized in Japan, was synthesized and tested in a graft-versus-host disease (GVHD) model in mice. " 01/28/1999 - "A series of new analogues of 15-deoxyspergualin (DSG), an immunosuppressive agent currently commercialized in Japan, was synthesized and tested in a graft-versus-host disease (GVHD) model in mice. " 05/01/1996 - "The effect of 15-deoxyspergualin (DSG) on bone marrow (BM) engraftment and graft-versus-host disease (GVHD) was studied in mice across both major (MHC) and minor (MiHC) histocompatibility barriers. "

Related Drugs and Biologics

1.	Cyclosporine (Ciclosporin)
2.	Antigens
3.	Immunosuppressive Agents (Immunosuppressants)
4.	Antineutrophil Cytoplasmic Antibodies (ANCA)
5.	mycophenolate mofetil (Cellcept)
6.	Sirolimus (Rapamycin)
7.	Prednisolone (Predate)
8.	Cyclophosphamide (Cytoxan)
9.	Doxorubicin (Adriamycin)
10.	Cytarabine (Cytosar-U)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Heart Transplantation (Grafting, Heart)
3.	Transplantation (Transplant Recipients)
4.	Photopheresis
5.	Radioimmunotherapy