gusperimus

synthesized by chemical modification of spergualin; in combination with cyclosporin A prevents diabetes in predisposed NOD mice; structure given in first source; RN given refers to (-)-isomer trihydrochloride

Also Known As:

1-amino-19-guanidino-11-hydroxy-4,9,12-triazanonadecane-10,13-dione; 15-deoxyspergualin; NKT-01; deoxyspergualin; gusperimus trihydrochloride; gusperimus, (+-)-isomer; Heptanamide, 7-((aminoiminomethyl)amino)-N-(2-((4-((3-aminopropyl)amino)butyl)amino)-1-hydroxy-2-oxoethyl)-

Networked: 126 relevant articles (11 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amidines: 14
  - Guanidines: 29
    - gusperimus: 126

Experts

1.	Nemoto, Kyuichi: 3 articles (03/2011 - 01/2006)
2.	Birck, Rainer: 3 articles (01/2006 - 02/2003)
3.	Heinzel, Peter A: 2 articles (03/2011 - 06/2005)
4.	Schmitt, Wilhelm H: 2 articles (03/2011 - 06/2005)
5.	Saiga, Kan: 2 articles (07/2010 - 05/2002)
6.	Flossmann, Oliver: 2 articles (03/2010 - 09/2008)
7.	Jayne, David R W: 2 articles (03/2010 - 09/2008)
8.	Hellmich, B: 2 articles (07/2009 - 12/2005)
9.	Nemoto, K: 2 articles (07/2009 - 12/2006)
10.	van der Woude, Fokko J: 2 articles (01/2006 - 06/2005)

Related Diseases

1.	Granulomatosis with Polyangiitis (Wegener's Granulomatosis) 06/01/2005 - "Prolonged treatment of refractory Wegener's granulomatosis with 15-deoxyspergualin: an open study in seven patients." 03/01/2010 - "Long-term treatment of relapsing Wegener's granulomatosis with 15-deoxyspergualin." 07/01/2009 - "Deoxyspergualin in relapsing and refractory Wegener's granulomatosis." 12/01/2006 - "15-Deoxyspergualin (DSG) is an alternative treatment modality for Wegener's granulomatosis (WG) patients refractory to conventional treatment. " 12/01/2006 - "In vivo effects of cyclic administration of 15-deoxyspergualin on leucocyte function in patients with Wegener's granulomatosis."
2.	Autoimmune Diseases (Autoimmune Disease) 06/23/1993 - "Preclinical studies with 15-deoxyspergualin in various animal models for autoimmune diseases." 01/01/1993 - "Immunosuppressive therapy of organ-specific nephritic autoimmune diseases with 15-deoxyspergualin." 09/01/1991 - "15-Deoxyspergualin (15-DOS) has a curative effect on the development of SLE-like autoimmune disease in MRL/1 mice." 09/01/1988 - "Biological activities of deoxyspergualin in autoimmune disease mice." 09/01/1995 - "Deoxyspergualin (DSG) is a potent immunosuppressive agent that is currently undergoing clinical trials for treatment of transplant rejection, preventive of human anti-mouse Ab response, and blocking autoimmune disease progression. "
3.	Coronary Artery Disease (Coronary Atherosclerosis) 02/01/1999 - "Inhibitory effect of 15-deoxyspergualin on coronary arteriosclerosis in the transplanted heart." 09/01/1994 - "We concluded that 15-Deoxyspergualin is superior to cyclosporine in preventing graft coronary arteriosclerosis after heart transplantation." 09/01/1994 - "The purpose of this study was to evaluate the effects of 15-Deoxyspergualin on graft coronary arteriosclerosis after heterotopic heart transplantation in a rat model and compare the effects to those of cyclosporine treatment. " 09/01/1994 - "Effects of cyclosporine and 15-deoxyspergualin on coronary arteriosclerosis after heart transplantation in the rat." 10/01/1993 - "The purpose of this study is to evaluate the effects of Cyclosporine (CsA), FK-506 (FK) and 15-Deoxyspergualin (DOS) on coronary arteriosclerosis after rat heart transplantation. "
4.	Glomerulonephritis 11/01/1999 - "Immunosuppressive effect of deoxyspergualin in proliferative glomerulonephritis." 01/01/1999 - "[Effects of deoxyspergualin on proliferative glomerulonephritis]." 05/01/1995 - "It has previously been shown that the immunosuppressive drug deoxyspergualin can inhibit renal injury in experimental glomerulonephritis. " 05/01/1993 - "Suppression of experimental crescentic glomerulonephritis by deoxyspergualin." 10/01/2005 - "Safety of 15-deoxyspergualin in the treatment of glomerulonephritis associated with active systemic lupus erythematosus."
5.	Graft vs Host Disease (Graft-Versus-Host Disease) 02/01/1988 - "The efficacy of 15-deoxyspergualin (15-DS) was tested in two models of experimental graft versus host disease (GvHD) in mice. " 05/01/1996 - "The effect of 15-deoxyspergualin (DSG) on bone marrow (BM) engraftment and graft-versus-host disease (GVHD) was studied in mice across both major (MHC) and minor (MiHC) histocompatibility barriers. " 03/01/1993 - "What role for 15-deoxyspergualin in enhancing engraftment of unrelated, histoincompatible canine marrow grafts and preventing graft-versus-host disease?" 03/01/1991 - "The beneficial effect of deoxyspergualin (DSG, NKT-01) on lethal graft-versus-host disease in mice has been studied in a major histoincompatible donor-recipient combination. " 03/01/1991 - "Deoxyspergualin in lethal murine graft-versus-host disease."

Related Drugs and Biologics

1.	Immunosuppressive Agents (Immunosuppressants)
2.	Cyclosporine (Ciclosporin)
3.	Antigens
4.	Antineutrophil Cytoplasmic Antibodies (ANCA)
5.	Mycophenolic Acid (Cellcept)
6.	Collagen Type II (Type II Collagen)
7.	Sirolimus (Rapamycin)
8.	Prednisolone (Predate)
9.	Cyclophosphamide (Cytoxan)
10.	Doxorubicin (Adriamycin)

Related Therapies and Procedures

1.	Heart Transplantation (Grafting, Heart)
2.	Transplantation
3.	Therapeutics
4.	Photopheresis
5.	Radioimmunotherapy