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phosphohomocyclocreatine
structure given in first source
Also Known As:
1-carboxyethyl-2-iminoimidazolidine-3-phosphate; homocyclocreatine-P; 1-Imidazolidinepropanoic acid, 2-imino-3-phosphono-
Networked:
3
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Amino Acids: 30675
Creatine: 3124
Phosphocreatine: 1826
phosphohomocyclocreatine: 3
Phosphoamino Acids: 1
Phosphocreatine: 1826
phosphohomocyclocreatine: 3
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Imidazoles: 150
Imidazolidines: 39
phosphohomocyclocreatine: 3
Related Diseases
1.
Neoplasms (Cancer)
04/20/1994 - "
Cyclocreatine was effective against a subset of tumors sensitive to homocyclocreatine (P = .023; Fisher's exact test), which was the more potent creatine analogue in this assay (P < .001; McNemar's test).
"
2.
Ischemia
05/01/1985 - "
During ischemia these hearts exhibited prolonged glycolysis, but they did not utilize the very stable homocyclocreatine-P (200,000-fold less reactive than creatine-P) and thus formed less Pi; most significantly, there was no delay in depletion of ATP levels relative to controls.
"
05/01/1985 - "
Decreases and oscillations in the [ATP]/[free ADP] ratio cannot be buffered effectively late in ischemia by the creatine-P system for thermodynamic reasons, or by the homocyclocreatine-P system because of kinetic limitations.
"
02/01/1983 - "
During ischemia homocyclocreatine-P was utilized by muscle much more slowly for the regeneration of ATP than was creatine-P or cyclocreatine-P.
"
02/01/1983 - "
Our results suggest that in tissues of homocyclocreatine-fed animals subjected to a sudden large increase in work load or to ischemia, the residual creatine-P system would rapidly equilibrate with the adenylate system at the new lower cytosolic phosphorylation potential, whereas in the same cytosol the (homocyclocreatine-P)/(homocyclocreatine) ratio would exhibit a hysteresis or memory effect and reflect for a considerable period of time the earlier higher (ATP)/(free ADP) ratio rather than the actual lower (ATP)/(free ADP) ratio.
"
Related Drugs and Biologics
1.
Creatine
2.
cyclocreatine
3.
Adenosine Triphosphate (ATP)
4.
Adenosine Diphosphate (ADP)
5.
homocyclocreatine