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phosphohomocyclocreatine

structure given in first source

Also Known As:

1-carboxyethyl-2-iminoimidazolidine-3-phosphate; homocyclocreatine-P; 1-Imidazolidinepropanoic acid, 2-imino-3-phosphono-

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Creatine: 3124
    - Phosphocreatine: 1826
      - phosphohomocyclocreatine: 3
  - Phosphoamino Acids: 1
    - Phosphocreatine: 1826
      - phosphohomocyclocreatine: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - Imidazolidines: 39
        phosphohomocyclocreatine: 3

Related Diseases

1.	Neoplasms (Cancer) 04/20/1994 - "Cyclocreatine was effective against a subset of tumors sensitive to homocyclocreatine (P = .023; Fisher's exact test), which was the more potent creatine analogue in this assay (P < .001; McNemar's test). "
2.	Ischemia 05/01/1985 - "During ischemia these hearts exhibited prolonged glycolysis, but they did not utilize the very stable homocyclocreatine-P (200,000-fold less reactive than creatine-P) and thus formed less Pi; most significantly, there was no delay in depletion of ATP levels relative to controls. " 05/01/1985 - "Decreases and oscillations in the [ATP]/[free ADP] ratio cannot be buffered effectively late in ischemia by the creatine-P system for thermodynamic reasons, or by the homocyclocreatine-P system because of kinetic limitations." 02/01/1983 - "During ischemia homocyclocreatine-P was utilized by muscle much more slowly for the regeneration of ATP than was creatine-P or cyclocreatine-P. " 02/01/1983 - "Our results suggest that in tissues of homocyclocreatine-fed animals subjected to a sudden large increase in work load or to ischemia, the residual creatine-P system would rapidly equilibrate with the adenylate system at the new lower cytosolic phosphorylation potential, whereas in the same cytosol the (homocyclocreatine-P)/(homocyclocreatine) ratio would exhibit a hysteresis or memory effect and reflect for a considerable period of time the earlier higher (ATP)/(free ADP) ratio rather than the actual lower (ATP)/(free ADP) ratio."

Related Drugs and Biologics

1.	Creatine
2.	cyclocreatine
3.	Adenosine Triphosphate (ATP)
4.	Adenosine Diphosphate (ADP)
5.	homocyclocreatine