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phosphatidylinositol 4-phosphate

Also Known As:
1-(3-sn-phosphatidylinositol)-L-myoinositol-4-phosphate; PI4P compound; PtdINS4P; phosphatidylinositol 4-monophosphate; phosphatidylinositol-4-phosphate
Networked: 79 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Malik, Sundeep: 3 articles (11/2018 - 03/2013)
2. Smrcka, Alan V: 3 articles (11/2018 - 03/2013)
3. Hancock, John F: 2 articles (12/2021 - 01/2021)
4. Kattan, Walaa E: 2 articles (12/2021 - 01/2021)
5. Yule, David I: 2 articles (11/2018 - 03/2013)
6. Jou, Ilo: 2 articles (01/2018 - 02/2013)
7. Lee, Sang Yoon: 2 articles (01/2018 - 02/2013)
8. Huang, Yan: 2 articles (06/2017 - 02/2016)
9. Ling, Kun: 2 articles (06/2017 - 02/2016)
10. Fukumoto, Miki: 2 articles (07/2016 - 06/2014)

Related Diseases

1. Neoplasms (Cancer)
2. Starvation
10/01/2023 - "Our data establishes a new mode of organelle contact formation - the ER-Golgi contact machinery can be reused by ER-autolysosome contacts by re-locating PtdIns4P from the Golgi apparatus to autolysosomes when faced with starvation.Abbreviations"
11/22/2023 - "Starvation-triggered relocalization of phosphatidylinositol 4-phosphate (PI(4)P)-metabolizing enzymes reshapes the lysosomal surface proteome to facilitate lysosomal proteolysis and to repress mTORC1 signaling. "
10/01/2023 - "In this study, we demonstrated that, upon starvation, autolysosomes recruit Pi4KIIα (Phosphatidylinositol 4-kinase II α) to generate phosphatidylinositol-4-phosphate (PtdIns4P) on their surface and establish endoplasmic reticulum (ER)-autolysosome contacts through PtdIns4P binding proteins Osbp (Oxysterol binding protein) and cert (ceramide transfer protein). "
10/01/2023 - ": Atg1: Autophagy-related 1; Atg8: Autophagy-related 8; Atg9: Autophagy-related 9; Atg12: Autophagy-related 12; cert: ceramide transfer protein; Cp1/CathL: cysteine proteinase-1; CTL: control; ER: endoplasmic reticulum; ERMCS: ER-mitochondria contact site; fwd: four wheel drive; GM130: Golgi matrix protein 130 kD; Osbp: Oxysterol binding protein; PG: phagophore; PtdIns4K: phosphatidylinositol 4-kinase; Pi4KIIα: Phosphatidylinositol 4-kinase II α; Pi4KIIIα: Phosphatidylinositol 4-kinase III α; PtdIns4P: phosphatidylinositol-4-phosphate; PR: photoreceptor cell; RT: room temperature; Sac1: Sac1 phosphatase; Stv: starvation; Syx17: Syntaxin 17; TEM: transmission electron microscopy; VAP: VAMP-associated protein."
01/01/2021 - ": Ape1: aminopeptidase Ι; ATG: autophagy related; EBSS: Earle's balanced salt solution; ER: endoplasmic reticulum; ERGIC: Golgi apparatus and ER-Golgi intermediate compartment; HOPS: homotypic fusion and protein sorting complex; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; PtdIns3P: phosphatidylinositol-3-phosphate; PtdIns4K: phosphoinositide-4-kinase; PtdIns4P: phosphatidylinositol-4-phosphate; SD-N: nitrogen starvation medium; SNARE: soluble N-ethylamide-sensitive factor attachment protein receptor."
3. Breast Neoplasms (Breast Cancer)
4. Infections
5. Hypoxia (Hypoxemia)
05/01/1991 - "It is shown that anoxia results in a small increase of phosphatidyl-inositol-4.5-bisphosphate (PIP2) and phosphatidylinositol-4-phosphate (PIP) content and in the depression of the turnover rate of all the phosphoinositides. "
03/01/1991 - "The dynamic of the phosphatidylinositol (PI), the phosphatidylinositol 4-phosphate (PIP) and the phosphatidylinositol-4,5-diphosphate (PIP2) contents were studied in the correlation with the neuronal spike activity in cat brain cortex under acute oxygen deficiency caused by cessation of artificial ventilation for 1, 2.5 and 5 min. It was shown that the 1-min anoxia produced the depression of both PIP and PIP2 contents. "
12/01/1988 - "The hypoxia-induced decrease in JF was associated with four- to fivefold increase in phosphatidylinositol 4-phosphate (PIP) total pool size, suggesting PIP kinase was inhibited and rate limiting. "
11/01/1994 - "During glucose-free hypoxia, phosphatidylinositol 4,5-bisphosphate, the substrate for phospholipase C, but not phosphatidylinositol or phosphatidylinositol 4-monophosphate was seen to decline to 59% of normoxic values which was independent of activation of phospholipase C by agonists. "
09/01/1989 - "ADP inhibited [32P]PtdIns4P formation competitively with respect to ATP, the Ki being 0.4 mM. The data indicate that ADP is a poor competitive inhibitor of PtdIns kinase at the concentrations which are believed to be present intracellularly normally or which may be attained during mild hypoxia provided ATP levels are maintained in the millimolar range. "

Related Drugs and Biologics

1. phosphatidylinositol 4-phosphate
2. Proteins (Proteins, Gene)
3. 1-Phosphatidylinositol 4-Kinase (1 Phosphatidylinositol 4 Kinase)
4. Ceramides
5. oxysterol binding protein
6. Carrier Proteins (Binding Protein)
7. Phosphatidylinositols (Phosphatidylinositol)
8. Phosphotransferases (Kinase)
9. Phosphatidic Acids (Phosphatidic Acid)
10. Nonesterified Fatty Acids (NEFA)