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concanamycin B

from Streptomyces diastatochromogenes S-45; structure given in first source

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Lactones: 1549
  - Macrolides: 4391
    - concanamycin B: 3
  - Polyketides: 231
    - Macrolides: 4391
      - concanamycin B: 3
Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Polyketides: 231
    - Macrolides: 4391
      - concanamycin B: 3

Experts

1.	Imoto, Masaya: 1 article (09/2002)
2.	Yoshimoto, Yuya: 1 article (09/2002)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 09/05/1993 - "We have examined the effects of concanamycin B on the constitutive secretory pathway of the human hepatoma cell line, HepG2. "
2.	Carcinoma (Carcinomatosis) 09/10/2002 - "In the course of screening for compounds that induce apoptosis in EGFR-overexpressing human epidermal carcinoma A431 cells from secondary metabolites of microorganisms, we found that vacuolar-type H(+)-ATPase (V-ATPase) inhibitors, such as concanamycin B and destruxin E, induced apoptosis only when the cells were stimulated with EGF. "
3.	Bone Resorption 02/01/1996 - "Concanamycin B, a vacuolar H(+)-ATPase specific inhibitor suppresses bone resorption in vitro." 02/01/1996 - "Effects of concanamycin B, a specific inhibitor of the vacuolar type H(+)-ATPase (V-ATPase), on the stimulation of bone resorption induced by parathyroid hormone (PTH) were examined in vitro. "

Related Drugs and Biologics

1.	Proton-Translocating ATPases (ATPase, H+)
2.	Adenosine Triphosphatases (ATPase)
3.	Vacuolar Proton-Translocating ATPases (V-Type ATPase)
4.	Parathyroid Hormone (Parathormone)
5.	Epidermal Growth Factor (EGF)
6.	destruxin E