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concanamycin A

from Streptomyces diastatochromogenes S-45; inhibits vacuolar H+ ATPase
Also Known As:
TAN 1323 B; TAN-1323 B; folimycin
Networked: 46 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Martín-Acebes, Miguel A: 2 articles (03/2011 - 12/2007)
2. Sobrino, Francisco: 2 articles (03/2011 - 12/2007)
3. Chai, Qingqing: 1 article (10/2022)
4. Johnson, Silas F: 1 article (10/2022)
5. Liu, Xin: 1 article (10/2022)
6. Lu, Xiaoran: 1 article (10/2022)
7. Schwartz, Richard C: 1 article (10/2022)
8. Sun, Liangliang: 1 article (10/2022)
9. Wang, Bin: 1 article (10/2022)
10. Yang, Zhichang: 1 article (10/2022)

Related Diseases

1. Infections
2. Neoplasms (Cancer)
3. Breast Neoplasms (Breast Cancer)
01/01/2019 - "To investigate how cancer cells respond to activated but ineffective T cells, we challenged peptide-loaded MCF-7 breast cancer cells with antigen-specific CD8+ T cells in which lytic granules had been destroyed by pretreatment with Concanamycin A. "
03/01/2012 - "To study the associated proteins, we isolated autophagosomes from human breast cancer cells using two different biochemical methods and three stimulus types: amino acid deprivation or rapamycin or concanamycin A treatment. "
01/01/2016 - "We also demonstrate that bLf decreases the extracellular acidification rate and causes intracellular acidification in metastatic breast cancer cells and, much like the well-known proton pump inhibitors concanamycin A and bafilomycin A1, inhibits V-H+-ATPase in sub-cellular fractions. "
05/18/1998 - "This report presents a quantification of the pH for identified compartments of the MCF-7 human breast tumor cell line and demonstrates that (a) the chemotherapeutic Adriamycin concentrates in acidified organelles of drug-resistant but not drug-sensitive cells; (b) the lysosomes and recycling endosomes are not acidified in drug-sensitive cells; (c) the cytosol of drug-sensitive cells is 0.4 pH units more acidic than the cytosol of resistant cells; and (d) disrupting the acidification of the organelles of resistant cells with monensin, bafilomycin A1, or concanamycin A is sufficient to change the Adriamycin distribution to that found in drug-sensitive cells, rendering the cell vulnerable once again to chemotherapy. "
4. Melanoma (Melanoma, Malignant)
5. Carcinoma (Carcinomatosis)

Related Drugs and Biologics

1. bafilomycin A1
2. Anti-Bacterial Agents (Antibiotics)
3. Macrolides
4. Viral Proteins
5. Proton-Translocating ATPases (ATPase, H+)
6. Adenosine Triphosphatases (ATPase)
7. Perforin
8. Proteins (Proteins, Gene)
9. Sirolimus (Rapamycin)
10. Granzymes (Granzyme)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)