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pteroylpentaglutamic acid
Also Known As:
Pte-penta-Glu; pteroylpentaglutamate
Networked:
2
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Pteridines: 147
Pterins: 160
Folic Acid: 19425
Pteroylpolyglutamic Acids: 12
pteroylpentaglutamic acid: 2
Related Diseases
1.
Carcinoma (Carcinomatosis)
09/01/1996 - "
The purpose of our study was to demonstrate that human prostatic carcinoma cells expressing PSM antigen exhibit folate hydrolase activity using methotrexate triglutamate (MTXGlu3) and pteroylpentaglutamate (PteGlu5) as substrates.
"
2.
Malaria
01/01/1989 - "
Inhibition of pteroylpentaglutamate synthesis from the radiolabelled metabolic precursors (GTP, PABA, L-Glu) and folate by the antifolate antimalarials, pyrimethamine and sulfadoxine at therapeutic concentrations, may suggest the existence of a unique biosynthetic pathway in the malaria parasite.
"
Related Drugs and Biologics
1.
Folic Acid (Vitamin M)
2.
Hydrolases
3.
human FOLH1 protein
4.
methotrexate polyglutamate
5.
Sulfadoxine (Sulformethoxine)
6.
Pyrimethamine (Daraprim)
7.
4-Aminobenzoic Acid (4 Aminobenzoic Acid)
8.
Guanosine Triphosphate (GTP)
9.
Folic Acid Antagonists
10.
Antimalarials (Antimalarial Agents)