tertiary- butyloxycarbonyl- valyl- prolyl- arginyl- 7- amino- 4- methylcoumarin

synthetic oligopeptide with fluorescent detector

Also Known As:

BOC-Val-Pro-Arg-7-amido-4-methylcoumarin; BVPAM; Boc-Val-Pro-Arg-MCA; L-Argininamide, N-((1,1-dimethylethoxy)carbonyl)-L-valyl-L-prolyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Coumarins: 826
        tertiary-butyloxycarbonyl-valyl-prolyl-arginyl-7-amino-4-methylcoumarin: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Coumarins: 826
        tertiary-butyloxycarbonyl-valyl-prolyl-arginyl-7-amino-4-methylcoumarin: 3
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - tertiary-butyloxycarbonyl-valyl-prolyl-arginyl-7-amino-4-methylcoumarin: 3

Related Diseases

1.	Neoplasms (Cancer) 07/01/1999 - "The protease catalyzing the hydrolysis of the tripeptide fluorescence substrate, butoxycarbonyl-valine-proline-arginine-(7-amino-4-methylcoumarin) (Boc-Val-Pro-Arg-MCA) and the neu oncogenic protein are potentially useful biomarkers for human cancer prevention studies. "
2.	Wounds and Injuries (Trauma) 10/01/1998 - "showed significantly higher hydrolytic activity-thrombin-like activity-toward Boc-Val-Pro-Arg-MCA than exudate from noninfected wounds. " 09/01/1997 - "In the first experiment using an infected dorsal pouch of rats, exudate containing proteinases from pouches contaminated with Staphylococcus aureus or Pseudomonas aeruginosa showed significantly higher hydrolytic activity toward Boc-Val-Pro-Arg-MCA than that from noninfected wounds. "

Related Drugs and Biologics

1.	Peptide Hydrolases (Proteases)
2.	Biomarkers (Surrogate Marker)
3.	Proteins (Proteins, Gene)
4.	Thrombin