ovomacroglobulin

macroglobulin from freshly laid egg white with protease inhib activity toward trypsin, papain, & thermolysin; contains 4 subunits of equal MW(175,000); subunit & amino acid comp related to human serum alpha-2 macroglobulin

Also Known As:

Networked: 15 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Huang, Ying-Xue: 2 articles (01/2018 - 11/2013)
2.	Shao, Xue-Bao: 2 articles (01/2018 - 11/2013)
3.	Sun, Jian-Fang: 2 articles (01/2018 - 11/2013)
4.	Xu, Xiu-Lian: 2 articles (01/2018 - 11/2013)
5.	Zeng, Xue-Si: 2 articles (01/2018 - 11/2013)
6.	Hawkridge, Adam M: 2 articles (09/2015 - 06/2013)
7.	Muddiman, David C: 2 articles (09/2015 - 06/2013)
8.	Petitte, James N: 2 articles (09/2015 - 06/2013)
9.	Qi, Jin-Liang: 1 article (01/2018)
10.	Song, Hao: 1 article (01/2018)

Related Diseases

1.	Dehydration (Water Stress) 12/01/2014 - "Optimization of native hα2 M crystals by varying chemical conditions was unsuccessful, while dehydration of native ovostatin crystals improved diffraction only slightly (10 Å). "
2.	Keratitis 01/01/1991 - "Spreading of Serratia marcescens in experimental keratitis and growth suppression by chicken egg white ovomacroglobulin." 01/01/1991 - "Inhibitory effects of ovomacroglobulin on bacterial keratitis in rabbits." 08/01/1994 - "Therapeutic intervention with chicken egg white ovomacroglobulin and a new quinolone on experimental Pseudomonas keratitis." 12/01/2013 - "Hen egg white (EW) are one of the most ideal sources of active proteins, and ovomacroglobulin, as a protease inhibitor, has been demonstrated to possess numerous biological properties including antibacterial and anti-inflammatory properties as well as activity for the treatment of keratitis. " 01/01/1991 - "We studied the inhibitory effects of chicken egg-white ovomacroglobulin (ovoM) on keratitis induced by 56,000-Da protease (56 KP) of Serratia marcescens and by elastase (PE) and alkaline protease (PAP) of Pseudomonas aeruginosa. "
3.	Neoplasms (Cancer) 09/01/2015 - "Of particular interest was ovostatin 2 (OVOS2), a novel 165-kDa protease inhibitor found to be strongly upregulated in chicken ovarian tumors (p = 0.0005) and matched plasma (p = 0.003). " 12/01/1989 - "Ovomacroglobulin and LDL fraction of egg yolk were effective to maintain the growth of established human cancer cell lines (Kato III, QG-90, Raji). "
4.	Cutaneous Malignant Melanoma 01/01/2018 - "We previously identified ovostatin 2 (OVOS2) as a new candidate gene for cutaneous malignant melanoma (CMM) in a Chinese population. " 01/01/2018 - "Ovostatin 2 knockdown significantly inhibits the growth, migration, and tumorigenicity of cutaneous malignant melanoma cells." 11/01/2013 - "Expression analysis of ovostatin 2 reveals its involvement in proliferation, invasion and angiogenesis of cutaneous malignant melanoma." 11/01/2013 - "The relationship of ovostatin 2 (OVOS2) expression with the clinicopathological features of cutaneous malignant melanoma (CMM) was investigated to identify OVOS2 expression in cutaneous melanocytic lesions, and to reveal whether OVOS2 has a function in melanoma progression. "
5.	Sepsis (Septicemia) 02/01/1998 - "Similarly, ovomacroglobulin, a potent inhibitor of the V. vulnificus protease, showed a strong suppressive effect on the V. vulnificus septicemia. "

Related Drugs and Biologics

1.	Protease Inhibitors (Protease Inhibitor)
2.	Peptide Hydrolases (Proteases)
3.	Proteins (Proteins, Gene)
4.	Pancreatic Elastase (Elastase)
5.	ovomacroglobulin
6.	Cathepsin A
7.	Complementary DNA (cDNA)
8.	Quinolones
9.	Sulfhydryl Compounds (Thiols)
10.	Sodium Dodecyl Sulfate (Sodium Lauryl Sulfate)