protease N

from Limulus amebocyte lysate; serine protease which acts on Factor Xa & thrombin substrate; not active on substrates cleaved by plasmin, kallikreins or urokinase

Networked: 9 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Cheng, Fu-Yuan: 1 article (02/2019)
2.	Lai, Kung-Ming: 1 article (02/2019)
3.	Lin, Liang-Chuan: 1 article (02/2019)
4.	Liu, Yu-Tse: 1 article (02/2019)
5.	Sakata, Ryoichi: 1 article (02/2019)
6.	Takeda, Shiro: 1 article (02/2019)
7.	Ban, Young-Hwan: 1 article (01/2017)
8.	Cha, Yeseul: 1 article (01/2017)
9.	Choi, Ehn-Kyoung: 1 article (01/2017)
10.	Guo, Haiyu: 1 article (01/2017)

Related Diseases

1.	Cognitive Dysfunction 01/01/2017 - "This study investigated the effects of a silk peptide fraction obtained by incubating silk proteins with Protease N and Neutrase (SP-NN) on cognitive dysfunction of Alzheimer disease model rats. "
2.	Virus Diseases (Viral Diseases) 02/14/2014 - "The objectives of this study were to detect viral infection in yaks in Qinghai, China and to determine the genotypes of BVDV based on analysis of the 5'untranslated region (5'UTR) and N-terminal protease (N(pro)) region. "
3.	Alzheimer Disease (Alzheimer's Disease) 01/01/2017 - "This study investigated the effects of a silk peptide fraction obtained by incubating silk proteins with Protease N and Neutrase (SP-NN) on cognitive dysfunction of Alzheimer disease model rats. "
4.	Diarrhea 10/01/2008 - "Importantly, the same applied to cells infected with bovine viral diarrhea virus (BVDV) expressing E(rns) but lacking the N-terminal protease N(pro). " 04/01/2011 - "Here we identify TRIM56 as a cellular protein associated with the N-terminal protease (N(pro)) of bovine viral diarrhea virus (BVDV), a pestiviral interferon antagonist which degrades interferon regulatory factor 3 (IRF3) through the proteasome. "
5.	Neurodegenerative Diseases (Neurodegenerative Disease) 02/01/2019 - "The results indicated the PBH, in particular EP (porcine brain extract with ethanol and protease N), demonstrated the potentials to reduce damage of neurodegenerative disorders in vitro and in vivo. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Silk
3.	5' Untranslated Regions (5' UTR)
4.	Peptides (Polypeptides)
5.	microbial metalloproteinases
6.	Interferons
7.	Enzymes
8.	Interferon Regulatory Factor-3 (Interferon Regulatory Factor 3)
9.	Proteasome Endopeptidase Complex (Proteasome)
10.	Collagenases (Collagenase)