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N,N,N'- trimethyl- N'- (2- hydroxy- 3- methyl- 5- iodobenzyl)- 1,3- propanediamine

brain perfusion imaging agent; structure given in first source

Also Known As:

(I-123)-HIPDM; HIPDM; Phenol, 2-(((3-(dimethylamino)propyl)methylamino)methyl)-4-(iodo-123I)-6-methyl-

Networked: 27 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Iodobenzenes
        N,N,N'-trimethyl-N'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propanediamine: 27
  - Halogenated Hydrocarbons: 42
    - Iodinated Hydrocarbons
      - Iodobenzenes
        N,N,N'-trimethyl-N'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propanediamine: 27

Related Diseases

1.	Stroke (Strokes) 12/01/1986 - "Blood flow maps are comparable to those achieved with [123I]HIPDM and established strokes were clearly seen, with similar details as in HIPDM studies. " 10/01/1984 - "Asymptomatic patients with history of transient ischemic attacks or minor stroke and angiographic evidence of internal carotid artery occlusion showed large cortical areas of reduced I-123 HIPDM distribution with normal or slightly positive CT. " 09/01/1990 - "To assess the clinical significance of transtentorial diaschisis (TTD) as demonstrated by I-123 HIPDM brain imaging, SPECT and/or planar images of 35 patients with stroke, 26 patients with Alzheimer's disease (AD), 2 patients with Creutzfeldt-Jakob disease (CJD), and 1 patient with a schizoaffective disorder were analyzed. " 07/01/1987 - "Early and late brain distribution of iodine-labelled N,N,N'-trimethyl-N'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propanediamine (HIPDM) and iodine labelled N-isopropyl-p-iodoamphetamine (IMP) were compared in rat and one human patient with a recent stroke in the right middle cerebral artery area. "
2.	Neoplasms (Cancer) 11/01/1986 - "Increased uptake of I-123 HIPDM occurred unexpectedly in two cases of intracranial tumors." 11/01/1986 - "Intracranial tumors: unexpected uptake of I-123 HIPDM." 05/01/1983 - "Patient studies with glioma revealed diminished HIPDm accumulation due to decreased flow and/or pH in the region of the neoplasm as well as in the associated vasogenic edema and overlying gray matter."
3.	Pancreatic Diseases (Pancreatic Disease) 11/01/1989 - "Comparative dual-tracer studies of carbon-14 tryptophan and iodine-131 HIPDM in animal models of pancreatic diseases."
4.	Glioma (Gliomas) 05/01/1983 - "In vivo quantitation of regional cerebral blood flow in glioma and cerebral infarction: validation of the HIPDm-SPECT method." 05/01/1983 - "Patient studies with glioma revealed diminished HIPDm accumulation due to decreased flow and/or pH in the region of the neoplasm as well as in the associated vasogenic edema and overlying gray matter."
5.	Edema (Dropsy) 05/01/1983 - "Patient studies with glioma revealed diminished HIPDm accumulation due to decreased flow and/or pH in the region of the neoplasm as well as in the associated vasogenic edema and overlying gray matter."

Related Drugs and Biologics

1.	Iodine-131
2.	Tryptophan (L-Tryptophan)
3.	Carbon-14
4.	N,N,N'- trimethyl- N'- (2- hydroxy- 3- methyl- 5- iodobenzyl)- 1,3- propanediamine
5.	Iodine-123
6.	Iofetamine (Iofetamine Hydrochloride, I 123)
7.	Pancreatic Elastase (Elastase)
8.	Iodine
9.	Inosine Monophosphate (IMP)
10.	Amines

Related Therapies and Procedures

1.	Gamma Cameras (Gamma Camera)