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5- acetylamino- 6- formylamino- 3- methyluracil

metabolite of caffeine

Also Known As:

AFMU; Acetamide, N-(4-(formylamino)-1,2,3,6-tetrahydro-1-methyl-2,6-dioxo-5-pyrimidinyl)-

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidinones: 71
      - Uracil: 1493
        5-acetylamino-6-formylamino-3-methyluracil: 3

Experts

1.	Cui, X: 1 article (04/2000)
2.	Guo, R: 1 article (04/2000)
3.	Li, C: 1 article (04/2000)
4.	Wang, B: 1 article (04/2000)
5.	Xu, Z: 1 article (04/2000)

Related Diseases

1.	Acquired Immunodeficiency Syndrome (AIDS) 12/01/1996 - "Twenty-one cases of advanced AIDS patients (CD4 < 200/microliter) were involved in this study, all Europeans except one black, were acetylate phenotyped via analysis of caffeine metabolites, named 5-Acetylamino-6-formylamino-3-methyluracil, 1-Methylxanthine and 5-Acetylamino-6-amino-3-methyluracil, in human urine collected 2 hours after a cup of caffeine-spiked coffee and their plasma/lymphocyte glutathione concentrations were determined, by high performance liquid chromatographic method. "
2.	Lung Neoplasms (Lung Cancer) 01/01/1988 - "In 220 of the lung cancer patients the N-acetyltransferase polymorphism was evaluated by means of the molar ratio of 5-acetylamino-6-formylamino-3-methyluracil and 1-methylxanthine in urine after ingestion of caffeine (coffee). "
3.	Urinary Bladder Neoplasms (Bladder Cancer) 04/01/2000 - "The peak height ratios of AFMU and 1X (AFMU/1X) were from 0.06 to 6.50 for healthy volunteers and 0.10 to 6.31 for patients with bladder cancer, both with the critical value of 1.10. "

Related Drugs and Biologics

1.	Coffee
2.	Caffeine (No Doz)
3.	1-methylxanthine
4.	Glutathione (Reduced Glutathione)
5.	5-acetylamino-6-amino-3-methyluracil
6.	Acetyltransferases