vernolepin

02/01/1983 - "Vernolepin, acting as a GSH-depleting agent, markedly sensitized tumor cells to lysis by H2O2 (greater than 6.5-fold increase with 20 micrograms/ml of vernolepin). "
06/19/1968 - "Vernolepin, a novel elemanolide dilactone tumor inhibitor from Vernonia hymenolepis."
08/01/1976 - "In vivo studies on the mechanism of action of the tumor inhibitor vernolepin in the Walker 256 carcinosarcoma."
07/13/1972 - "Inactivation of glycogen synthase by the tumor inhibitor vernolepin."
12/01/1969 - "Vernolepin, a novel sesquiterpene dilactone tumor inhibitor from Vernonia hymenolepis A. "

01/01/2022 - "The present study demonstrated the anti‑proliferative effect and apoptosis‑inducing activity of three sesquiterpene lactones isolated from Gymnanthemum extensum, vernodalin (VDa), vernolepin (VLe) and vernolide (VLi), on A549 human lung cancer cells. "

08/01/1976 - "In vivo studies on the mechanism of action of the tumor inhibitor vernolepin in the Walker 256 carcinosarcoma."
08/01/1976 - "Rats bearing the Walker 256 intramuscular carcinosarcoma were treated intraperitoneally with tritium-labeled vernolepin or with its nontumor-inhibitory methanol adduct. "

08/01/1985 - "We found here that lysis of P815 mastocytoma cells by vernolepin, with or without BSO, required cystine in the culture medium. "
02/01/1983 - "Incubation of P815 mastocytoma cells with any of the four SL tested (vernolepin, helenalin, elephantopin, and eriofertopin) for 1 h resulted in 70-97% depletion of GSH. "

11/01/2019 - "Our results indicated that vernodalin, vernolepin, and vernolide have potential to be used as lead compounds in the development of a therapeutic natural product for treatment of liver cancer."
11/01/2019 - "Vernodalidimer L, a sesquiterpene lactone dimer from Vernonia extensa and anti-tumor effects of vernodalin, vernolepin, and vernolide on HepG2 liver cancer cells."