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bestrabucil
cpd from reaction of chlorambucil and estradiol; structure
Also Known As:
KM 2210; KM-2210; Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 3-benzoate 17-((4-(4-(bis(2-chloroethyl)amino)phenyl)-1-oxobutoxy)acetate)
Networked:
17
relevant articles (
3
outcomes,
3
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Halogenated Hydrocarbons: 42
Mustard Compounds: 3
Nitrogen Mustard Compounds: 2
Chlorambucil: 1430
bestrabucil: 17
Polycyclic Compounds: 6
Fused-Ring Compounds
Steroids: 70059
Estranes
Estrenes
Estradiol: 14115
bestrabucil: 17
Hormones, Hormone Substitutes, and Hormone Antagonists
Hormones: 80400
Gonadal Hormones: 716
Gonadal Steroid Hormones: 7657
Estradiol Congeners: 358
Estradiol: 14115
bestrabucil: 17
Related Diseases
1.
Carcinoma (Carcinomatosis)
10/01/1987 - "
[A case of carcinoma in the lower abdomen treated successfully with oral administration of bestrabucil].
"
10/01/1984 - "
After a single oral administration of 100 mg/kg of bestrabucil to female Wistar rats bearing Walker 256 carcinoma, bestrabucil accumulated significantly occurred in tumor tissues with little or no accumulation in normal tissues and blood.
"
10/01/1984 - "
Anti-tumor effects and toxicities of bestrabucil and chlorambucil, were compared using Walker 256 carcinoma.
"
06/01/1984 - "
KM 2210, a combination product of 17 beta-estradiol and chlorambucil, was administered to 15 patients with advanced (stage C and D) prostatic carcinoma.
"
06/01/1984 - "
[Clinical application of KM 2210 (estradiol-chlorambucil) in patients with advanced prostatic carcinoma].
"
2.
T-Cell Leukemia (Leukemia, T Cell)
09/01/1986 - "
That is, Bestrabucil was effective in all three patients with T-cell leukemia, both with essential thrombocytosis and two of the three with lymphoma.
"
3.
Thrombocytosis (Thrombocythemia)
09/01/1986 - "
That is, Bestrabucil was effective in all three patients with T-cell leukemia, both with essential thrombocytosis and two of the three with lymphoma.
"
4.
Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular)
09/01/1986 - "
[Bestrabucil-induced complete remission in a case of follicular lymphoma, medium-sized cell type, stage IV (leukemic)].
"
09/01/1986 - "
Bestrabucil, a chlorambucil-estradiol conjugate known to accumulate in malignant cells irrespective of the presence or absence of estrogen receptor, was administered to a 41-year-old man with follicular lymphoma, medium-sized cell type (LSG classification) stage IV (leukemic).
"
5.
Lymphoma (Lymphomas)
09/01/1986 - "
That is, Bestrabucil was effective in all three patients with T-cell leukemia, both with essential thrombocytosis and two of the three with lymphoma.
"
Related Drugs and Biologics
1.
Estrogen Receptors
2.
Interferon-alpha (Interferon Alfa)
3.
Chlorambucil (Leukeran)
4.
Estradiol (Delestrogen)
5.
Benzoates (Benzoate)
6.
bestrabucil
7.
Fibroblast Growth Factor 8
8.
Intercellular Signaling Peptides and Proteins (Growth Factors)
9.
Mitomycin (Mitomycin-C)
10.
Esters
Related Therapies and Procedures
1.
Oral Administration
2.
Therapeutics
3.
Drug Therapy (Chemotherapy)