toosendanin

06/01/2004 - "Cure of experimental botulism and antibotulismic effect of toosendanin."
03/01/1985 - "The effect of toosendanin on monkey botulism."
11/01/2011 - "Toosendanin, a triterpenoid from Melia toosendan Sieb et Zucc, has been found before to be an effective anti-botulism agent, with a bi-phasic effect at both motor nerve endings and central synapse: an initial facilitation followed by prolonged depression. "
09/15/2011 - "Toosendanin, a drug with therapeutic effects against botulism, inhibited GT1b-dependent BoNT/B oligomerization and in parallel truncated BoNT/B single-channel conductance, suggesting that oligomerization plays a role in the translocation reaction. "
06/01/2004 - "In spite of sharing some similar action with BoNT, toosendanin can protect botulism animals that have been administrated with lethal doses of BoNT/A or BoNT/B for several hours from death and make them restore normal activity. "

01/01/2021 - "Toosendanin Shows Potent Efficacy Against Human Ovarian Cancer through Caspase-Dependent Mitochondrial Apoptotic Pathway."
01/01/2023 - "Toosendanin reduces cisplatin resistance in ovarian cancer through modulating the miR-195/ERK/β-catenin pathway."

09/01/2010 - "In this study we used both in vivo and in vitro models to investigate the anti-cancer effects of toosendanin and their possible molecular mechanisms. "
12/01/2005 - "In the present study, we investigated the growth inhibition and apoptosis-induced effect of toosendanin on human cancer cells. "
01/01/2023 - "Toosendanin (TSN) is a natural anti-cancer compound that is isolated from the traditional Chinese herbal Melia toosendan Sieb et Zucc. "
01/01/2022 - "Here, we report the identification of a potent autophagy inhibitor toosendanin which can effectively block autophagosome maturation, causing the accumulation of autophagy substrates in multiple cancer cells. "
12/01/2021 - "Toosendanin (TSN) is a crucial component from Toosendan Fructus with a promising anti-tumor capacity. "

11/23/2017 - "In this study, we identify Toosendanin (TSN) is an effective inhibitor of STAT3, leading to the impediment of various oncogenic processes in osteosarcoma. "
06/01/2019 - "Correction: Toosendanin demonstrates promising antitumor efficacy in osteosarcoma by targeting STAT3."
11/23/2017 - "Toosendanin demonstrates promising antitumor efficacy in osteosarcoma by targeting STAT3."

01/01/2018 - "Natural product toosendanin reverses the resistance of human breast cancer cells to adriamycin as a novel PI3K inhibitor."
01/01/2018 - "In this study, we found for the first time that toosendanin (TSN), a triterpenoid extracted from the traditional Chinese medicine Melia toosendan Sieb et Zucc, could successfully reverse adriamycin resistance in human breast cancer cells. "