2-deoxy-2,3-dehydro-N-acetylneuraminic acid

also known as NeuAc2en, but this is also synonym for another compound

Also Known As:

2,3-dehydro-2-deoxy-N-acetylneuraminic acid; 2,3-dehydro-2-deoxyneuraminic acids; 2,3-didehydro-2-deoxy-N-acetylneuraminic acid; 2-DDANA; 2-acetyl-2,3-didehydro-2-deoxyneuraminic acid; 2-deoxy-2,3-didehydro-N-acetylneuraminic acid; 5-acetamido-2,6-anhydro-3,5-dideoxy-D-glycero-D-galacto-non-2-enoic acid; Neu5Ac2en; deoxy-N-acetylneuraminic acid; deoxysialic acid; D-glycero-D-galacto-Non-2-enonic acid, 5-(acetylamino)-2,6-anhydro-3,5-dideoxy-

Networked: 23 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	von Itzstein, Mark: 5 articles (06/2017 - 01/2007)
2.	Dyason, Jeffrey C: 3 articles (06/2017 - 03/2007)
3.	Thomson, Robin J: 2 articles (06/2017 - 03/2007)
4.	Haselhorst, Thomas: 2 articles (09/2014 - 01/2007)
5.	Suzuki, Takashi: 2 articles (03/2007 - 03/2004)
6.	Suzuki, Yasuo: 2 articles (03/2007 - 03/2004)
7.	Atamas, Sergei P: 1 article (01/2021)
8.	Cairo, Christopher W: 1 article (01/2021)
9.	Goldblum, Simeon E: 1 article (01/2021)
10.	Hyun, Sang W: 1 article (01/2021)

Related Diseases

1.	Infections 04/01/2001 - "In addition, 4-O-thiocarbamoylmethyl-Neu5Ac2en strongly inhibited hPIV-1 infections of Lewis lung carcinoma-monkey kidney cells in comparison with Neu5Ac2en. " 02/01/2017 - "On the other hand, 2-deoxy-2,3-dehydro-N-acetylneuraminic acid, classic sialidase inhibitor, negatively regulates E. tarda infection of goldfish scale GAKS cells. " 12/01/2012 - "Intranasal zanamivir and Neu5Ac2en were 70 to 100% protective against influenza A/NWS/33 (H1N1) virus infections at 0.1 to 10 and 30 to 100 mg/kg/day, respectively. " 03/31/2007 - "In this study, after the existence of a CD44 homolog in alligators was established by immunolabeling primary pulmonary fibroblasts with monoclonal antibody IM7 against murine CD44, the sialidase inhibitor 2,3-didehydro-2-deoxy-N-acetylneuraminic acid (DANA) was used to examine the effects of sialidase on fibroblast apoptosis following in vitro infection with M. "
2.	Human Influenza (Influenza) 08/01/1971 - "[Influence of 2-deoxy-2,3-dehydro-N-acetylneuraminic acid on Myxovirus-neuraminidases and the replication of influenza- and Newcastle disease virus]." 09/01/2001 - "Limited optimization of the pyrrolidine series resulted in a compound which was about 24-fold more potent than 2-deoxy-2,3-dehydro-N-acetylneuraminic acid in an anti-influenza cell culture assay using A/N2/Victoria/3/75 virus. " 12/01/2012 - "Intranasal zanamivir and Neu5Ac2en were 70 to 100% protective against influenza A/NWS/33 (H1N1) virus infections at 0.1 to 10 and 30 to 100 mg/kg/day, respectively. " 09/15/1993 - "We have determined the crystal structure at 1.8 A resolution of two complexes of influenza B/Beijing neuraminidase containing either the reaction product, sialic acid, or the transition state analogue inhibitor, 2,3-dehydro-2-deoxy-N-acetylneuraminic acid (DANA). " 06/05/2009 - "Peracetylated Neu5Ac2en methyl ester, an intermediate in the synthesis of the influenza neuraminidase inhibitor Relenza, has been synthesized in high yields from peracetylated Neu5Ac methyl ester by flash vacuum pyrolysis. "
3.	Neoplasms (Cancer) 08/01/2009 - "Primary NK cells and the NK line NK-92 lysed NDV-infected tumor cells with enhanced efficiency, an effect that was eliminated by the treatment of target cells with the neuraminidase inhibitor Neu5Ac2en. " 09/15/1987 - "Treatment of tumor cells with sialidase greatly reduced the lectin-dependent agglutination, and the sialidase-dependent reduction of tumor cell agglutination was inhibited by the sialidase inhibitor 2,3-dehydro-2-deoxy-N-acetylneuraminic acid. "
4.	Paramyxoviridae Infections (Parainfluenza) 03/15/2007 - "Synthesis and evaluation of 4-O-alkylated 2-deoxy-2,3-didehydro-N-acetylneuraminic acid derivatives as inhibitors of human parainfluenza virus type-3 sialidase activity." 02/01/1993 - "The inhibition of sialidase activity from influenza viruses A and B, parainfluenza 2 virus, Vibrio cholerae, Arthrobacter ureafaciens, Clostridium perfringens, and sheep liver by a range of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid analogues modified at the C-4 position has been studied. " 05/31/1990 - "Membrane preparations of guinea-pig lung (containing multiple muscarinic receptor subtypes) and heart (containing M2 receptors only) were incubated with either neuraminidase, parainfluenza virus (which contains neuraminidase), or virus plus 2,3-dehydro-2-deoxy-N-acetylneuraminic acid, a neuraminidase inhibitor. " 09/25/2014 - "In this study, we explore the effect of C-5 modifications on the potency of Neu5Ac2en derivatives that target the human parainfluenza type-1 hemagglutinin-neuraminidase protein. " 09/25/2014 - "These findings shed light on the importance of C-5 substitution on Neu5Ac2en in the design of novel sialic acid-based inhibitors that target human parainfluenza type-1 hemagglutinin-neuraminidase. "
5.	Sialic Acid Storage Disease (Salla Disease) 08/01/1975 - "Isolation and identification of 2-deoxy-2,3-dehydro-N-acetylneuraminic acid from the urine of a patient with sialuria." 08/01/1975 - "N-Acetylneuraminic acid preparations from the urine of a patient with sialuria contain 1--2% of 2-deoxy-2,3-dehydro-N-acetylneuraminic acid. " 03/22/1979 - "A new metabolite, namely 2-acetamidoglucal, has been found in the urine of a patient with sialuria in addition to the metabolites N-acetylneuraminic acid, N-acetylmannosamine, N-acetylglucosamine and 2-deoxy-2,3-dehydro-N-acetylneuraminic acid reported earlier. "

Related Drugs and Biologics

1.	Neuraminidase (Sialidase)
2.	Zanamivir (Relenza)
3.	Proteins (Proteins, Gene)
4.	Hemagglutinins (Hemagglutinin)
5.	Monoclonal Antibodies
6.	N-Acetylneuraminic Acid (Sialic Acid)
7.	2-deoxy-2,3-dehydro-N-acetylneuraminic acid
8.	Lectins
9.	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)
10.	Glycoproteins (Glycoprotein)

Related Therapies and Procedures

1.	Lasers (Laser)