3,4,5-trihydroxybenzohydroxamic acid

01/01/1985 - "DBD in combination with VF-122 exhibited additive lethality against hepatoma cells in culture. "
12/01/1982 - "Proliferating and resting hepatoma 3924A cells recovered from sublethal and potentially lethal damage induced by VF 122."
12/01/1982 - "Exponentially growing hepatoma 3924A cells were more sensitive to VF 122 than were plateau-phase cultures. "
12/01/1982 - "In contrast, hydroxyurea killed only exponentially growing 3924A hepatoma cells, exhibiting an exponential plateau dose-response curve without achieving achieving an IC50 value at concentrations from 1 to 200 mM. In synchronized cultures, VF 122 (1 MM for 1 hr) was toxic for cells in mid and late G1 phase, in early and mid S phase, and, to a lesser degree, in G2 phase, Hydroxyurea (10 mM for 1 hr) killed cells only in S phase. "
12/01/1982 - "3, 4, 5-Trihydroxybenzohydroxamic acid (VF 122), an inhibitor of ribonucleotide reductase, killed rat hepatoma 3924A cells in tissue cultured after 7 days of incubation. "

01/01/1985 - "Acivicin, pyrazofurin, tiazofurin and VF-122 were lethal against tumor cells in the exponential phase of growth with IC50 of 1.5, 5, 10 and 4.5 microM, respectively. "