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VLDL receptor

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Also Known As:

VLDLR protein, human; Vldlr protein, mouse; Vldlr protein, rat; beta-VLDL receptor; receptor, VLDL; very low density lipoprotein receptor, human; very low density lipoprotein receptor, mouse; very low density lipoprotein receptor, rat; very low density lipoprotein receptors

Networked: 45 relevant articles (5 outcomes, 5 trials/studies)

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Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Membrane Proteins: 5300
    - Cell Surface Receptors: 753
      - Lipoprotein Receptors: 157
        LDL Receptors: 2588
        VLDL receptor: 45

Experts

1.	Vaziri, Nosratola D: 5 articles (11/2009 - 01/2002)
2.	Takahashi, Sadao: 4 articles (04/2011 - 06/2003)
3.	Miyamori, Isamu: 3 articles (04/2011 - 06/2003)
4.	Hattori, Hiroaki: 3 articles (04/2011 - 01/2004)
5.	Yamamoto, Tokuo T: 3 articles (04/2011 - 06/2003)
6.	Liang, Kaihui: 3 articles (07/2004 - 01/2002)
7.	Liang, Yongjun: 2 articles (11/2014 - 01/2014)
8.	Zhang, Peng: 2 articles (11/2014 - 01/2014)
9.	Wang, Tingfeng: 2 articles (11/2014 - 01/2014)
10.	Qiao, Zhengdong: 2 articles (11/2014 - 01/2014)

Related Diseases

1.	Hypertriglyceridemia 03/22/2002 - "Possible causes of hypertriglyceridemia and reduced body mass with VLDL receptor deficiency." 01/01/1985 - "Fifth, our observations suggest that the abnormal catabolism of VLDL that occurs in hypertriglyceridemia may be explained by the abnormal uptake of HTG-VLDL by either the LDL or the beta-VLDL receptor pathway. " 03/01/1998 - "Role of secondary hyperparathyroidism in the genesis of hypertriglyceridemia and VLDL receptor deficiency in chronic renal failure." 07/01/2004 - "Hypertriglyceridemia in nephrotic syndrome is accompanied by increased hepatic fatty acid synthesis, elevated triglyceride secretion, as well as lipoprotein lipase, VLDL-receptor, and hepatic triglyceride lipase deficiencies, which lead to impaired clearance of triglyceride-rich lipoproteins. " 07/01/2004 - "The metabolic flow of lipoproteins in normo- and hypertriglyceridemia can be described by separate compartments that contribute to lipoprotein interaction with at least six different receptors: 1) low density lipoprotein (LDL) receptor; 2) LDL receptor-related protein (LRP); 3) apoB(48) macrophage receptor for hypertriglyceridemic very low density lipoproteins (VLDL); 4) scavenger receptors; 5) VLDL receptor; 6) lipolysis-stimulated receptor. "
2.	Atherosclerosis 01/01/2000 - "Although the VLDL receptor has been shown to play an important role in the proliferation of vascular smooth muscle cells and the formation of foam cells as primary responses of atherogenesis, its actual functions are still unclear. " 12/01/1996 - "Our findings suggest that the VLDL receptor expression may play a role in the development of atherosclerosis." 04/22/2011 - "Since VLDL receptor is expressed on macrophages in atheromatous plaques of both rabbit and human but not in mouse models, the mechanisms of atherogenesis and/or growth of atherosclerotic lesions in mouse models may be partly different from those of humans and rabbits." 01/01/2004 - "Recently, various functions of the VLDL receptor have been reported in lipoprotein metabolism, metabolic syndrome/atherosclerosis, cardiac fatty acid metabolism, neuronal migration and angiogenesis/tumor growth. " 01/01/1998 - "This finding substantiates a possible role for the VLDL receptor in atherosclerosis in hyperlipidemic subjects homozygous for apoE2 or carrying apoE3-Leiden and indicates that the VLDL receptor expressed on the liver has therapeutic potential as an alternative route for clearance of binding-defective lipoproteins."
3.	Proteinuria 11/01/2003 - "This study tested the hypothesis that amelioration of proteinuria by protein restriction or use of oral adsorbent AST-120 beginning at 10 weeks of age may improve renal disease and LPL and VLDL receptor deficiencies in Imai rats. " 11/01/2003 - "Protein restriction mitigated the decline in creatinine clearance, ameliorated proteinuria, hypoalbuminemia, hypertension, and hypercholesterolemia, lowered plasma VLDL, and improved plasma postheparin LPL activity, hepatic lipase activity, LPL, and VLDL receptor proteins in skeletal muscle and adipose tissue. "
4.	Hypertension (High Blood Pressure) 12/01/1995 - "2. We studied the gene expression of the VLDL receptor in the heart of stroke-prone spontaneously hypertensive rats (SHRSP), an animal model for hypertension-induced cardiac hypertrophy. " 12/01/1995 - "RNase protection assay showed that the level of ventricular VLDL receptor mRNA was already decreased to one half when hypertension was not fully developed, and further diminished to one fifth when cardiac hypertrophy was established. " 11/01/2003 - "Protein restriction mitigated the decline in creatinine clearance, ameliorated proteinuria, hypoalbuminemia, hypertension, and hypercholesterolemia, lowered plasma VLDL, and improved plasma postheparin LPL activity, hepatic lipase activity, LPL, and VLDL receptor proteins in skeletal muscle and adipose tissue. "
5.	Hypercholesterolemia 01/01/1998 - "Reversal of hypercholesterolemia in apolipoprotein E2 and apolipoprotein E3-Leiden transgenic mice by adenovirus-mediated gene transfer of the VLDL receptor." 11/01/2003 - "Protein restriction mitigated the decline in creatinine clearance, ameliorated proteinuria, hypoalbuminemia, hypertension, and hypercholesterolemia, lowered plasma VLDL, and improved plasma postheparin LPL activity, hepatic lipase activity, LPL, and VLDL receptor proteins in skeletal muscle and adipose tissue. "

Related Drugs and Biologics

1.	Lipoproteins (Lipoprotein)
2.	Lipase (Acid Lipase)
3.	Lipoprotein Lipase (Diacylglycerol Lipase)
4.	LDL-Receptor Related Protein 1 (LDL-Receptor Related Protein)
5.	Pre-beta High-Density Lipoproteins
6.	Apolipoprotein E2
7.	Apolipoprotein C-III
8.	Gemfibrozil (Lopid)
9.	Proteins (Proteins, Gene)
10.	Creatinine