ataprost

Also Known As:

15-cyclopentyl-omega-pentanor-5(E)-carbacyclin; ONO 41483; ONO-41483; OP 41483; ataprost, 3aS-(3aalpha,4alpha(1E,3R*),5beta,6aalpha)-isomer; Pentanoic acid, 5-(4-(3-cyclopentyl-3-hydroxy-1-propenyl)hexahydro-5-hydroxy-2(1H)-pentalenylidene)-, (3aS-(2E,3aalpha,4alpha(1E,3R*),5beta,6aalpha))-

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Lipids: 114793
- Fatty Acids: 27405
  - Unsaturated Fatty Acids: 8236
    - Eicosanoids: 3262
      - Prostaglandins: 17100
        Prostaglandins I: 108
        Epoprostenol: 4670
        ataprost: 7
Biological Factors: 2472
- Inflammation Mediators: 1113
  - Autacoids: 276
    - Eicosanoids: 3262
      - Prostaglandins: 17100
        Prostaglandins I: 108
        Epoprostenol: 4670
        ataprost: 7

Related Diseases

1.	Hypothermia 11/01/1989 - "The study suggests that OP-41483 is one of the useful agents to maintain coronary circulation and myocardial metabolism under simple deep hypothermia."
2.	Ischemia 05/01/1993 - "The best protective effect was seen when 1,000 ng/kg/min OP-41483 was administered before and after the ischemia. " 11/01/1988 - "Experimentally, 45 isolated perfused newborn rabbit hearts (age, 0-2 days) underwent 2 hours of global ischemia at 15 degrees C with a single dose of GIK cardioplegic solution and were subsequently assigned to three groups: Group 1 hearts (n = 15) were infused with basic GIK cardioplegic solution alone (no added calcium, but measured at 0.1-0.2 mM/l); Group 2 hearts (n = 15) received GIK cardioplegic solution with calcium (1.2 mM); and Group 3 hearts (n = 15) received GIK cardioplegic solution with calcium and a PGI2 analogue (OP-41483, 300 micrograms/l). "
3.	Peripheral Vascular Diseases (Peripheral Vascular Disease) 05/01/1992 - "These results indicate that OP-41483.alpha-CD has antiplatelet and cutaneous blood flow improving activities that are greater than its hypotensive effect and may be of therapeutic potential in peripheral vascular diseases."
4.	Thrombosis (Thrombus) 01/01/1990 - "3) In the electrically induced thrombosis model of guinea pig mesenteric artery, OP-41483 (300-1000 ng/kg/min, i.v.-infusion) and OP-41483 alpha-CD (1.0-3.0 mg/kg, p.o.) inhibited thrombus formation, but heparin (1.0-10 U/kg/min, i.v.-infusion) did not. " 01/01/1990 - "4) In the rabbit extracorporeal circulation thrombosis model, OP-41483 (100 and 300 ng/kg/min, i.v.-infusion) inhibited thrombus formation in the extracorporeal shunt and prevented the decrease in platelet count, hematocrit and fibrinogen level in circulating blood. "
5.	Spasm (Spasms) 09/01/1982 - "In addition, bolus intravenous doses (3 to 10 micrograms/kg) of ONO 41483 reversed vasopressin-induced ECG changes in the monkey, suggesting an ability of the compound to relieve coronary spasm."

Related Drugs and Biologics

1.	Vasopressins (Vasopressin)
2.	Heparin (Liquaemin)
3.	Fibrinogen (Factor I)
4.	Ergotamine (Ergotamine Tartrate)
5.	Epinephrine (Adrenaline)
6.	Cardioplegic Solutions
7.	Calcium
8.	Alprostadil (Muse)

Related Therapies and Procedures

1.	Extracorporeal Circulation