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Quin2

fluorescent highly selective Ca indicator, binding Ca 1:1; structure given in first source
Also Known As:
Quin 2; Quin-2; Glycine, N-(2-((8-(bis(carboxymethyl)amino)-6-methoxy-2-quinolinyl)methoxy)-4-methylphenyl)-N-(carboxymethyl)-
Networked: 67 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Bai, H: 1 article (08/2001)
2. Lu, J H: 1 article (08/2001)
3. Ou, Y X: 1 article (08/2001)
4. Wei, Y M: 1 article (08/2001)
5. Zheng, R L: 1 article (08/2001)

Related Diseases

1. Small Cell Lung Carcinoma (Small Cell Lung Cancer)
2. Lung Neoplasms (Lung Cancer)
3. Essential Hypertension
4. Neuroblastoma
5. Hypertension (High Blood Pressure)
04/01/1990 - "Thus, 1) in the same population a higher resting (Ca)i was detected in platelets from essential hypertensives with Fura 2, but not with Quin 2; and 2) Ca2+ release from internal stores is altered in hypertension. "
10/01/1984 - "Using the fluorescent Ca-dependent dye quin-2 the authors measured the concentrations of free calcium in the platelet cytoplasm of rats with spontaneous hypertension (SHR) and in normotensive rats (NKWR) serving as control. "
02/01/1992 - "To investigate the role of cytosolic free calcium, [Ca2+]i, in secondary hypertension, the levels in platelets from 14 secondary hypertensives (7 renovascular hypertension, 7 primary aldosteronism) were compared with those from 21 essential hypertensives and 15 normotensives by means of the fluorescent indicator, quin-2. "
06/01/1986 - "To test the hypothesis that an abnormality of the intracellular concentration of ionized calcium, [Ca2+]i, is associated with high blood pressure, we measured [Ca2+]i in the platelets of spontaneously hypertensive (SHR) and Wistar-Kyoto control (WKY) rats using the Quin 2 technique after separation of the platelets in calcium-free medium, during calcium repletion, and upon exposure to agonists which increase platelet [Ca2+]i (thrombin, adenosine diphosphate, serotonin and ionomycin). "
12/01/1988 - "Cardiac calcium channels and platelet Ca2+ concentrations were examined in deoxycorticosterone acetate (DOCA)-salt hypertension in rats to clarify the role of calcium channels in the regulation of intracellular Ca2+. Calcium channels were determined by the radioligand binding method and platelet Ca2+ concentrations were measured by a fluorescent Ca2+ indicator, Quin-2. "

Related Drugs and Biologics

1. Calcium
2. Bombesin
3. Intercellular Signaling Peptides and Proteins (Growth Factors)
4. Gastrin-Releasing Peptide
5. Peptides (Polypeptides)
6. Indicators and Reagents (Reagents)
7. Fluorescent Dyes (Fluorescent Probes)
8. Fura-2 (Fura 2)
9. Carbachol (Carbastat)
10. Thrombin

Related Therapies and Procedures

1. Sympathectomy (Sympathectomies)
2. Subcutaneous Injections