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Quin2
fluorescent highly selective Ca indicator, binding Ca 1:1; structure given in first source
Also Known As:
Quin 2; Quin-2; Glycine, N-(2-((8-(bis(carboxymethyl)amino)-6-methoxy-2-quinolinyl)methoxy)-4-methylphenyl)-N-(carboxymethyl)-
Networked:
67
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Quinolines: 146
Aminoquinolines: 29
Quin2: 67
Experts
1.
Bai, H
: 1 article (08/2001)
2.
Lu, J H
: 1 article (08/2001)
3.
Ou, Y X
: 1 article (08/2001)
4.
Wei, Y M
: 1 article (08/2001)
5.
Zheng, R L
: 1 article (08/2001)
Related Diseases
1.
Small Cell Lung Carcinoma (Small Cell Lung Cancer)
12/05/1987 - "
To examine the biochemical basis for growth factor-induced responses in human lung cancer cells, we used the quin2 technique to study the effect of the amphibian peptide bombesin and its congeners including mammalian gastrin-releasing peptide (GRP) on the intracellular free calcium level [Ca2+]i in small cell lung cancer cell lines.
"
2.
Lung Neoplasms (Lung Cancer)
12/05/1987 - "
To examine the biochemical basis for growth factor-induced responses in human lung cancer cells, we used the quin2 technique to study the effect of the amphibian peptide bombesin and its congeners including mammalian gastrin-releasing peptide (GRP) on the intracellular free calcium level [Ca2+]i in small cell lung cancer cell lines.
"
3.
Essential Hypertension
03/01/1987 - "
Platelet intracellular free calcium concentration was assessed by the quin-2 method in 38 patients with essential hypertension and in 35 normotensive subjects.
"
01/01/1985 - "
Intraplatelet free [Ca2+] was studied in human primary hypertension using the fluorescent indicator Quin-2.
"
04/01/1990 - "
It was reported that in essential hypertension, basal platelet free cytosolic (Ca)i measured with the fluorescent dye Quin 2, is elevated, but increases normally after thrombin stimulation.
"
08/01/1989 - "
1. Resting and stimulated free calcium concentrations have been measured in platelets loaded with the fluorescent probe quin2 from 30 patients with essential hypertension and from 30 age-matched controls.
"
05/01/1988 - "
Platelet activation factor (PAF)-, ADP and vasopressin-induced increments of platelet Ca2+ concentration were measured by quin-2 in 64 patients with essential hypertension and 16 normal donors.
"
4.
Neuroblastoma
08/15/1989 - "
When SK-N-SH human neuroblastoma cells were exposed to nicotine (NIC) or KCl they showed a dose-dependent transient increase (2- to 4-fold) in intracellular Ca2+ concentration ([Ca2+])i as detected by quin-2 fluorescence, with half maximal effects (EC50) observed at 13 microM and 26 mM, respectively.
"
01/01/1987 - "
Muscarinic receptor-linked increases in intracellular free Ca2+ as measured with quin-2 and Ca2+ release from monolayers of cells have been measured in the human neuroblastoma cell line SH-SY5Y.
"
05/01/1988 - "
Depolarization of differentiated neuroblastoma X glioma (NG108-15) cells with KCl (50 mM) or veratridine (50 microM) stimulated Ca2+ accumulation, was detected by quin 2 fluorescence.
"
05/01/1988 - "
Voltage-sensitive calcium channels in differentiated neuroblastoma X glioma hybrid (NG108-15) cells: characterization by quin 2 fluorescence.
"
06/01/1988 - "
Intracellular calcium homeostasis and its modulation by different agents was studied in control and differentiated IMR32 human neuroblastoma cells by using the Ca2+-sensitive fluorescent dye quin2.
"
5.
Hypertension (High Blood Pressure)
04/01/1990 - "
Thus, 1) in the same population a higher resting (Ca)i was detected in platelets from essential hypertensives with Fura 2, but not with Quin 2; and 2) Ca2+ release from internal stores is altered in hypertension.
"
10/01/1984 - "
Using the fluorescent Ca-dependent dye quin-2 the authors measured the concentrations of free calcium in the platelet cytoplasm of rats with spontaneous hypertension (SHR) and in normotensive rats (NKWR) serving as control.
"
02/01/1992 - "
To investigate the role of cytosolic free calcium, [Ca2+]i, in secondary hypertension, the levels in platelets from 14 secondary hypertensives (7 renovascular hypertension, 7 primary aldosteronism) were compared with those from 21 essential hypertensives and 15 normotensives by means of the fluorescent indicator, quin-2.
"
06/01/1986 - "
To test the hypothesis that an abnormality of the intracellular concentration of ionized calcium, [Ca2+]i, is associated with high blood pressure, we measured [Ca2+]i in the platelets of spontaneously hypertensive (SHR) and Wistar-Kyoto control (WKY) rats using the Quin 2 technique after separation of the platelets in calcium-free medium, during calcium repletion, and upon exposure to agonists which increase platelet [Ca2+]i (thrombin, adenosine diphosphate, serotonin and ionomycin).
"
12/01/1988 - "
Cardiac calcium channels and platelet Ca2+ concentrations were examined in deoxycorticosterone acetate (DOCA)-salt hypertension in rats to clarify the role of calcium channels in the regulation of intracellular Ca2+. Calcium channels were determined by the radioligand binding method and platelet Ca2+ concentrations were measured by a fluorescent Ca2+ indicator, Quin-2.
"
Related Drugs and Biologics
1.
Calcium
2.
Bombesin
3.
Intercellular Signaling Peptides and Proteins (Growth Factors)
4.
Gastrin-Releasing Peptide
5.
Peptides (Polypeptides)
6.
Indicators and Reagents (Reagents)
7.
Fluorescent Dyes (Fluorescent Probes)
8.
Fura-2 (Fura 2)
9.
Carbachol (Carbastat)
10.
Thrombin
Related Therapies and Procedures
1.
Sympathectomy (Sympathectomies)
2.
Subcutaneous Injections