(3-methyl-2-oxobutanoate dehydrogenase (lipoamide)) kinase

acts on 2-oxoisovalerate dehydrogenase (lipoamide) EC 1.2.4.4

Also Known As:

2-OA-dehydrogenase kinase; AKIVD-kinase; BCAKAD kinase; BCKA dehydrogenase kinase; BCKAD kinase; BCKADC kinase; alpha-ketoisovalerate dehydrogenase kinase; branched chain 2-ketoacid dehydrogenase kinase; branched chain 2-oxoacid dehydrogenase kinase; branched-chain 2-oxovalerate dehydrogenase (lipoamide) kinase; branched-chain alpha-keto acid dehydrogenase kinase; branched-chain alpha-ketoacid dehydrogenase kinase

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9677
        (3-methyl-2-oxobutanoate dehydrogenase (lipoamide)) kinase: 5

Experts

1.	Bajotto, Gustavo: 1 article (03/2010)
2.	Doisaki, Masao: 1 article (03/2010)
3.	Feng, Guo-Gang: 1 article (03/2010)
4.	Fujita, Yuko: 1 article (03/2010)
5.	Goto, Hidemi: 1 article (03/2010)
6.	Hayashi, Kazuhiko: 1 article (03/2010)
7.	Hirooka, Yoshiki: 1 article (03/2010)
8.	Ishigami, Masatoshi: 1 article (03/2010)
9.	Ishikawa, Naohisa: 1 article (03/2010)
10.	Itoh, Akihiro: 1 article (03/2010)

Related Diseases

1.	Starvation 03/01/2001 - "Well established among these are the alpha-keto acid produced by leucine transamination, which is a potent inhibitor of the kinase, and starvation for dietary protein, which causes increased expression of the branched-chain alpha-keto acid dehydrogenase kinase. "
2.	Hepatocellular Carcinoma (Hepatoma) 01/01/2000 - "Regulation of branched-chain alpha-keto acid dehydrogenase kinase gene expression by glucocorticoids in hepatoma cells and rat liver."
3.	Type 2 Diabetes Mellitus (MODY) 03/05/2010 - "Regulation of hepatic branched-chain alpha-keto acid dehydrogenase kinase in a rat model for type 2 diabetes mellitus at different stages of the disease."
4.	Breast Neoplasms (Breast Cancer) 01/01/2023 - "Inhibition of branched-chain alpha-keto acid dehydrogenase kinase augments the sensitivity of ovarian and breast cancer cells to paclitaxel."
5.	Body Weight (Weight, Body) 07/01/1990 - "Administration of alpha-ketoisocaproate (200 mumol/100 g body weight, an inhibitor of BCKAD kinase) reversed the meal-feeding-induced inactivation of the complex within 10 min. We conclude that the frequency of food intake, in addition to the level of dietary protein, influences the proportion of liver BCKAD in the active state. "

Related Drugs and Biologics

1.	Dietary Proteins
2.	Paclitaxel (Taxol)
3.	Phosphotransferases (Kinase)
4.	Leucine (L-Leucine)
5.	Glucocorticoids
6.	Acids
7.	alpha-ketoisocaproic acid