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2- N,N- di- n- propylamino- 4,7- dimethoxyindan
dopamine receptor agonist; structure given in first source
Also Known As:
RDS 127; RDS-127; 1H-Inden-2-amine, 2,3-dihydro-4,7-dimethoxy-N,N-dipropyl-
Networked:
5
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Polycyclic Aromatic Hydrocarbons: 2020
Indenes: 4
Indans: 7
2-N,N-di-n-propylamino-4,7-dimethoxyindan: 5
Polycyclic Compounds: 6
Polycyclic Aromatic Hydrocarbons: 2020
Indenes: 4
Indans: 7
2-N,N-di-n-propylamino-4,7-dimethoxyindan: 5
Related Diseases
1.
Glucose Intolerance
09/01/1984 - "
Adrenodemedullation blocked the glucose intolerance and inhibition of insulin release caused by RDS-127, whereas these effects of TL-99 were not attenuated.(ABSTRACT TRUNCATED AT 250 WORDS)
"
2.
Tremor (Tremors)
03/01/1990 - "
Both TL-68 and RDS-127 inhibited the tremor intensity but were less potent than atropine.
"
3.
Hypothermia
12/01/1982 - "
Also, RDS-127 produced hypothermia following lateral ventricular (i.c.v.) administration.
"
12/01/1982 - "
The hypothermia produced by apomorphine or RDS-127 (given s.c.
"
12/01/1982 - "
Apomorphine (APO) or RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane), two DA receptor agonists, produced dose-dependent hypothermia following subcutaneous (s.c.) administration.
"
4.
Hypotension (Low Blood Pressure)
05/01/1984 - "
The bradycardic effect was 20.5 times more potent when the drug was administered intracerebroventricularly (i.c.v.) than when given i.v. RDS-127 produced a slight, but significant hypotension.
"
05/01/1984 - "
These results suggest that RDS-127 activates central DA receptors to produce hypotension and bradycardia in rats.
"
5.
Hyperglycemia
03/01/1984 - "
The hyperglycemia produced by APO or RDS-127 was blocked by adrenalectomy, adrenodemedullation or prior administration of pimozide, a DA receptor antagonist.
"
03/01/1984 - "
Phentolamine, an alpha adrenergic receptor antagonist had no effect on the hyperglycemia induced by APO or RDS-127.
"
03/01/1984 - "
The following synthetic, structural analogs of dopamine (DA) were examined for their ability to produce hyperglycemia in conscious unrestrained rats: APO (apomorphine), RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane), di-n-propyldopamine, 2-di-n-propylamino-5,6-dihydroxytetralin, 2-dimethylamino-6,7-dihydroxytetralin, lergotrile, pergolide, bromocriptine and d-amphetamine.
"
Related Drugs and Biologics
1.
Apomorphine
2.
alpha Adrenergic Receptors
3.
Pimozide (Orap)
4.
Phentolamine (Z-Max)
5.
Pergolide (Permax)
6.
Insulin (Novolin)
7.
Dopamine (Intropin)
8.
Dextroamphetamine (Dexedrine)
9.
Bromocriptine (Parlodel)
10.
Atropine
Related Therapies and Procedures
1.
Adrenalectomy