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somatotropin (177-191)
Also Known As:
AOD-9401; hGH (177-191); human growth hormone (177-191); L-Phenylalanine, L-leucyl-L-arginyl-L-isoleucyl-L-valyl-L-glutaminyl-L-cysteinyl-L-arginyl-L-seryl-L-valyl-L-alpha-glutamylglycyl-L-seryl-L-cysteinylglycyl-, cyclic (6-13)-disulfide
Networked:
4
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Peptides: 82426
Peptide Hormones: 1347
Pituitary Hormones: 601
Anterior Pituitary Hormones: 187
Growth Hormone: 14884
somatotropin (177-191): 4
Peptide Fragments: 373
somatotropin (177-191): 4
Hormones, Hormone Substitutes, and Hormone Antagonists
Hormones: 80400
Peptide Hormones: 1347
Pituitary Hormones: 601
Anterior Pituitary Hormones: 187
Growth Hormone: 14884
somatotropin (177-191): 4
Experts
1.
Heffernan, M A
: 1 article (09/2000)
2.
Jiang, W J
: 1 article (09/2000)
3.
Ng, F M
: 1 article (09/2000)
4.
Thorburn, A W
: 1 article (09/2000)
Related Diseases
1.
Obesity
09/01/2000 - "
The marked lipolytic and antilipogenic actions of AOD-9401 in human adipose tissues suggest that this small synthetic hGH peptide has potential in the treatment of human obesity.
"
08/01/1994 - "
The hGH 177-191 peptide has the potential to be an effective compound for the treatment of human obesity and for the improvement of meat qualities in farm animals.
"
2.
Body Weight (Weight, Body)
08/01/1994 - "
Results indicate that the hGH 177-191 reduced the cumulative body weight gain, and decreased the adipose tissue mass.
"
08/01/1994 - "
Reduction of cumulative body weight gain and adipose tissue mass in obese mice: response to chronic treatment with synthetic hGH 177-191 peptide.
"
12/01/1978 - "
The effect for hGH 177--191 was short-lived, and synthase activity had returned to normal levels by 15 min, whereas the action of hGH 6--13 was of longer duration and was still quite marked at 60 min. Both peptides showed a linear dependence of response to the log dose of peptide injected over the range 0.1--250 microgram hGH 6--13 per kg body weight and 0.05--25 microgram hGH 177--191 per kg body weight.
"
3.
Weight Gain
09/01/2000 - "
Together, these findings indicate that oral administration of AOD-9401 alters lipid metabolism in adipose tissue, resulting in a reduction of weight gain in obese animals.
"
4.
Insulin Resistance
09/01/1982 - "
Two of the peptides, Cam-hGH 177--191 and cam-hGH 177--191 were, in nanomolar quantities, both active in that they caused significant hyperglycaemia and insulin resistance in normal rats.
"
Related Drugs and Biologics
1.
Peptides (Polypeptides)
2.
somatotropin (6-13)
Related Therapies and Procedures
1.
Oral Administration