Sch 28080

not related structurally to other known anti-ulcer agents; inhibits histamine-stimulated gastric secretion; prevents gastric lesions induced by aspirin, indomethacin & ethanol

Also Known As:

2-methyl-8-(phenylmethoxy)imidazo-(1-2-a)pyrine-3-acetonitrile; S28080; Sch-28080; Sch28080; Schering compound 28080; Imidazo(1,2-a)pyridine-3-acetonitrile, 2-methyl-8-(phenylmethoxy)-

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - Sch 28080: 7

Experts

1.	Beyreis, Marlena: 1 article (01/2017)
2.	Fürst, Johannes: 1 article (01/2017)
3.	Gaisberger, Martin: 1 article (01/2017)
4.	Hauser-Kronberger, Cornelia: 1 article (01/2017)
5.	Jakab, Martin: 1 article (01/2017)
6.	Ketterl, Nina: 1 article (01/2017)
7.	Kiesslich, Tobias: 1 article (01/2017)
8.	Kittl, Michael: 1 article (01/2017)
9.	Ritter, Markus: 1 article (01/2017)

Related Diseases

1.	Acidosis 08/01/1997 - "In contrast, in cells preconditioned to low pH (7.0) to simulate chronic acidosis, the enhanced pHi recovery was abolished by bafilomycin A1 but not by Sch-28080. " 10/01/1998 - "In tubules from the terminal segment of the inner medullary collecting duct (tIMCD) from rats with chronic metabolic acidosis, our laboratory has shown that bicarbonate absorption (JtCO2) is inhibited by removal of K+ from the luminal fluid or by the addition of Sch-28080 to the perfusate. " 11/01/1994 - "During 18 h of severe acidosis there was a significant decrease in Jsec (-15 +/- 3 vs. -38 +/- 5 pmol.min-1.mm-1, P < 0.05) and a significant increase in Jreab (37 +/- 6 vs. 0 +/- 5 pmol.min-1.mm-1, P < 0.05), which was insensitive to 10(-5) M bafilomycin A1, 10(-5) M Sch-28080, and 3 mM amiloride. "
2.	Ulcer 10/25/1986 - "N-ethylmaleimide pretreatment of this gradient fraction uncovered a vesicle population with characteristics similar to the gastric H+,K+ATPase: proton transport was abolished by orthovanadate and the experimental anti-ulcer drug SCH 28080, was enhanced by potassium, and was not affected by chloride. "
3.	Stomach Ulcer (Gastric Ulcer) 07/01/1983 - "SCH 28080 (1-30 mg/kg p.o.) also inhibited gastric ulcers provoked by aspirin, aspirin + acid, indomethacin and stress (cold-restraint) in rats. "
4.	Insulinoma 01/01/2017 - "The H+/K+ ATPase Inhibitor SCH-28080 Inhibits Insulin Secretion and Induces Cell Death in INS-1E Rat Insulinoma Cells." 01/01/2017 - "To investigate if other proton extrusion mechanisms than NHEs are involved in pH regulation, we tested for the presence of the non-gastric H+/K+ ATPase in rat insulinoma cells and assessed effects of the H+/K+ ATPase inhibitor SCH-28080 on insulin secretion, cell viability and apoptosis. "
5.	Hypokalemia 08/01/1997 - "In cells grown in low-K+ (2.5 mM) media to simulate chronic hypokalemia, pHi recovery was significantly faster than in cells grown in normal K+ media (delta pHi/min = 0.045 +/- 0.01 vs. 0.014 +/- 0.001, P < 0.01) and was inhibited specifically by Sch-28080, not by bafilomycin A1. "

Related Drugs and Biologics

1.	Protons (Proton)
2.	bafilomycin A1
3.	Vanadates (Orthovanadate)
4.	Potassium
5.	Phenobarbital (Luminal)
6.	Indomethacin (Indometacin)
7.	Ethylmaleimide (N-Ethylmaleimide)
8.	Chlorides
9.	Bicarbonates (Hydrogen Carbonate)
10.	Aspirin (Acetylsalicylic Acid)