forms alpha-amide from C-terminal glycine precursor of peptide hormones by oxidation of hydrogen & spontaneous hydrolysis of resulting imino linkage; posseses both an alpha-hydroxylation domain (PHM) and an alpha-amidation domain (PAL); PAM refers to the bifunctional enzyme; may be the same as bovine Somatotropin; RefSeq NM_013626 (mouse), NM_013000 (rat), NM_138822 (human)
Also Known As:
AE-II protein, Xenopus; Pam protein, mouse; Pam protein, rat; SP-GLYE protein, human; alpha-amidating enzyme AE-II; alpha-amidation monooxygenase; peptide C-terminal alpha-amidating enzyme II, Xenopus; peptidyl alpha-amidating monooxygenase; peptidyl-glycine alpha-amidating monooxygenase; peptidylglycine 2-hydroxylase; peptidylglycine alpha-amidating monooxygenase; peptidylglycine alpha-amidating monooxygenase, mouse; peptidylglycine alpha-amidating monooxygenase, rat; peptidylglycine alpha-hydroxylating monooxygenase; peptidylglycine hydroxylase; substance P-Gly12 protein, human