drospirenone

a progestational compound with antimineralocorticoid and antiandrogenic activity; structure given in first source

Also Known As:

1,2-dihydro-spirorenone; 1,2-dihydrospirorenone; 6beta,7beta,15beta,16beta-dimethylen-3-oxo-17alpha-pregn-4-en-21,17-carbolacton; ZK 30595; ZK30595; dihydrospirorenone; Spiro(17H-dicyclopropa(6,7:15,16)cyclopenta(a)phenanthrene-17,2'(5'H)-furan)-3,5'(2H)-dione, 1,3',4',6,7,8,9,10,11,12,13,14,15,16,20,21-hexadecahydro-10,13-dimethyl-, (6R-(6alpha,7alpha,8beta,9alpha,10beta,13beta,14alpha,15alpha,16alpha,17beta))-

Networked: 341 relevant articles (49 outcomes, 97 trials/studies)

Relationship Network

Drug Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Androstanes: 11
      - Androstenes: 5
        drospirenone: 341

Experts

1.	Marr, Joachim: 12 articles (01/2015 - 09/2004)
2.	Colli, Enrico: 9 articles (04/2022 - 12/2019)
3.	Regidor, Pedro-Antonio: 7 articles (04/2022 - 12/2019)
4.	Palacios, Santiago: 6 articles (04/2022 - 12/2019)
5.	Kunz, Michael: 6 articles (05/2012 - 06/2007)
6.	Sampson-Landers, Carole: 6 articles (09/2009 - 09/2004)
7.	Heithecker, R: 6 articles (09/2003 - 03/2000)
8.	Foidart, Jean-Michel: 5 articles (05/2021 - 01/2006)
9.	Momoeda, Mikio: 5 articles (01/2020 - 01/2014)
10.	Fruzzetti, Franca: 5 articles (02/2018 - 03/2007)

Related Diseases

1.	Acne Vulgaris 09/01/2008 - "This drospirenone-containing COC has been shown to be effective in reducing both inflammatory and noninflammatory acne lesions." 09/01/2007 - "With the accumulating evidence on the efficacy and safety of drospirenone-containing hormonal preparations, this formulation provides dermatologists with a new treatment option for acne and other hyperandrogenic disorders." 11/01/2002 - "Drospirenone's antiandrogenic activity, for example, makes it effective in reducing acne and seborrhea. " 12/01/2000 - "Pre-existing acne and seborrhea were improved by ethinylestradiol/ drospirenone and blood pressure was essentially unchanged. " 01/01/2015 - "The contraceptive efficacy, improvement in acne, and relief from PMDD symptoms observed in these studies did not differ from the effects observed in other international studies of EE 20 µg/drospirenone 3 mg, indicating that EE 20 µg/drospirenone 3 mg is as effective in Chinese women as in other ethnicities. "
2.	Dysmenorrhea (Menstrual Pain) 01/01/2017 - "The aim of this study was to assess the safety and efficacy of a flexible extended regimen of ethinylestradiol/drospirenone (flexible regimen) in Japanese women with dysmenorrhea. " 01/01/2020 - "This study characterized HRQoL in Japanese women with dysmenorrhea before and after ethinylestradiol/drospirenone (EE/DRSP) treatment. " 01/01/2020 - "Burden of Menstrual Pain Measured by Heatmap Visualization of Daily Patient-Reported Data in Japanese Patients Treated with Ethinylestradiol/Drospirenone: A Randomized Controlled Study." 01/01/2017 - "Efficacy and safety of a flexible extended regimen of ethinylestradiol/drospirenone for the treatment of dysmenorrhea: a multicenter, randomized, open-label, active-controlled study." 01/01/2020 - "Quality of Life in Japanese Patients with Dysmenorrhea Treated with Ethinylestradiol 20 μg/Drospirenone 3 mg in a Real-World Setting: An Observational Study."
3.	Premenstrual Dysphoric Disorder 10/01/2010 - "The efficiency of oral contraception containing drospirenone in treating symptoms of premenstrual dysphoric disorder (PMDD) was demonstrated in a number of studies. " 09/01/2005 - "Efficacy of a new low-dose oral contraceptive with drospirenone in premenstrual dysphoric disorder." 07/01/2014 - "[Efficacy and safety of a combined oral contraceptive containing drospirenone 3 mg and ethinylestradiol 20 µg in the treatment of premenstrual dysphoric disorder: a randomized, double blind placebo-controlled study]." 02/15/2012 - "Drospirenone 3 mg plus ethinyl estradiol 20 μg may help treat premenstrual symptoms in women with severe symptoms, that is, premenstrual dysphoric disorder. " 07/01/2011 - "A combined oral contraceptive comprising ethinylestradiol (EE) 20 mcg/drospirenone 3 mg in a 24/4 regimen has been clinically shown to alleviate the symptoms associated with premenstrual dysphoric disorder (PMDD). "
4.	Hyperandrogenism 12/01/2010 - "evaluate the efficacy of an estroprogestin EP containing 20 mcg ethinilestradiol (EE) and 3 mg drospirenone (DRSP) in the treatment of hyperandrogenism. " 12/01/2010 - "[Short-term effect of an estroprogestin containing ethinylestradiol 20 mcg + drospirenone 3 mg in 24+4 regimen at hormonal and cutaneous level in ovarian hyperandrogenism]." 02/01/2006 - "Non-obese, young patients (n = 31) with hyperinsulinaemic hyperandrogenism were started on Flu-Met (21/28 days) and randomized to receive in addition either a drospirenone oral contraceptive or a transdermal contraceptive for 6 months. " 01/01/2006 - "To prove the clinical efficiency over hyperandrogenism in women with PCOS after the application of the combined oral contraceptive Yasmin containing 30 mcg ethynilestradiol and 2 mg drospirenone. " 09/01/2004 - "Flutamide-metformin plus ethinylestradiol-drospirenone for lipolysis and antiatherogenesis in young women with ovarian hyperandrogenism: the key role of early, low-dose flutamide."
5.	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 01/01/2011 - "Effects of drospirenone pill in Indian women with polycystic ovary syndrome." 02/01/2010 - "Drospirenone and cardiovascular risk in lean and obese polycystic ovary syndrome patients: a pilot study." 04/01/2008 - "Use of ethinylestradiol/drospirenone combination in patients with the polycystic ovary syndrome." 06/01/2004 - "Drospirenone for the treatment of hirsute women with polycystic ovary syndrome: a clinical, endocrinological, metabolic pilot study." 03/01/2007 - "Efficacy of an oral contraceptive containing drospirenone in the treatment of women with polycystic ovary syndrome."

Related Drugs and Biologics

1.	Ethinyl Estradiol (Estinyl)
2.	Combined Oral Contraceptives
3.	Oral Contraceptives
4.	Desogestrel
5.	Contraceptive Agents (Contraceptives)
6.	Progestins (Progestagens)
7.	Tablets
8.	Chlormadinone Acetate (Chlormadinone)
9.	Hormones (Hormone)
10.	Cyproterone Acetate

Related Therapies and Procedures

1.	Contraception (Birth Control)
2.	Therapeutics
3.	Aftercare (After-Treatment)
4.	Ovulation Inhibition
5.	Hormone Replacement Therapy (Therapy, Hormone Replacement)