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thiolactomycin

from actinomycetes; structure given in first source

Also Known As:

2(5H)-Thiophenone, 4-hydroxy-3,5-dimethyl-5-(2-methyl-1,3-butadienyl)-, (S-(E))-

Networked: 10 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiophenes: 257
    - thiolactomycin: 10
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Thiophenes: 257
    - thiolactomycin: 10

Experts

1.	Berry, Colin: 2 articles (09/2005 - 02/2004)
2.	Brun, Reto: 2 articles (09/2005 - 02/2004)
3.	Gilbert, Ian H: 2 articles (09/2005 - 02/2004)
4.	Harwood, John L: 2 articles (09/2005 - 02/2004)
5.	Jones, Simon M: 2 articles (09/2005 - 02/2004)
6.	Urch, Jonathan E: 2 articles (09/2005 - 02/2004)
7.	Besra, Gurdyal S: 2 articles (11/2003 - 10/2002)
8.	Ashour, Mohamed L: 1 article (09/2021)
9.	Musayeib, Nawal M Al: 1 article (09/2021)
10.	Ovidi, Elisa: 1 article (09/2021)

Related Diseases

1.	Tuberculosis (Tuberculoses) 12/06/2006 - "Thiolactomycin, a clinical candidate for treatment of tuberculosis has led to further explorations in this class. " 06/01/2019 - "The in silico drug designing methods used in this study suggests that the thiolactomycin derivatives are having a better binding activity against MTB-KasA and among them the ligand C14 is identified as a promising lead molecule to inhibit multidrug resistance of tuberculosis by showing a long time binding activity." 11/03/2003 - "tuberculosis mycolic acid biosynthesis, compared to thiolactomycin." 10/01/2002 - "tuberculosis strains with multicopy inhA or kasAB plasmids, were tested for their resistance to INH, ethionamide (ETH) or thiolactomycin (TLM). " 09/18/2021 - "tuberculosis KasA (β-ketoacyl synthases) with a high fitting score (∆G = -15.57 kcal/mol) approaching that of isoniazid and exceeding that of thiolactomycin, the co-crystallized ligand. "
2.	Obesity 02/24/2005 - "These studies identify thiolactomycin as a promising template for the development of new selective cancer and obesity treatments."
3.	Neoplasms (Cancer) 02/24/2005 - "These studies identify thiolactomycin as a promising template for the development of new selective cancer and obesity treatments."
4.	Malaria 02/15/2004 - "A series of analogues of the naturally occurring antibiotic thiolactomycin (TLM) have been synthesised and evaluated for their ability to inhibit the growth of the malaria parasite, Plasmodium falciparum. " 09/22/2005 - "Analogues of the natural antibiotic thiolactomycin (TLM), an inhibitor of the condensing reactions of type II fatty acid synthase, were synthesized and evaluated for their ability to inhibit the growth of the malaria parasite Plasmodium falciparum. "
5.	Periodontal Diseases (Periodontal Disease) 12/01/1990 - "Antimicrobial activities of thiolactomycin against gram-negative anaerobes associated with periodontal disease. "

Related Drugs and Biologics

1.	Ligands
2.	Mycolic Acids (Mycolic Acid)
3.	Isoniazid (Ftivazide)
4.	Anti-Bacterial Agents (Antibiotics)
5.	Type II Fatty Acid Synthase
6.	Triclosan (pHisoHex)
7.	Ethionamide (Trecator-SC)