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piperazine

RN given refers to parent cpd; synonym pripsen refers to unspecified salt

Also Known As:

1,4-piperazine; Pripsen; piperazine diacetate; piperazine dihydrochloride; piperazine hexahydrate; piperazine hydrate; piperazine hydrobromide; piperazine hydrochloride; piperazine monohydrochloride; piperazine phosphate; piperazine phosphate (1:1); piperazine salt; piperazine sulfate; piperazine tartrate (1:1), (R-(R*,R*))-isomer; piperazine tartrate, (R-(R*,R*))-isomer; piperazinium oleate

Networked: 462 relevant articles (21 outcomes, 49 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Piperazines: 18
    - piperazine: 462

Experts

1.	Li, Zhiyu: 3 articles (09/2015 - 01/2009)
2.	Guo, Qinglong: 3 articles (09/2015 - 01/2009)
3.	Lu, Na: 3 articles (09/2015 - 06/2011)
4.	You, Qidong: 3 articles (01/2014 - 01/2009)
5.	Berardi, Francesco: 3 articles (09/2011 - 12/2009)
6.	Perrone, Roberto: 3 articles (09/2011 - 12/2009)
7.	Abate, Carmen: 3 articles (09/2011 - 12/2009)
8.	Najajreh, Yousef: 3 articles (06/2007 - 11/2002)
9.	Gibson, Dan: 3 articles (06/2007 - 11/2002)
10.	Supuran, Claudiu T: 2 articles (09/2015 - 08/2009)

Related Diseases

1.	Infection 07/30/1988 - "A controlled trial was performed to evaluate the efficacy of piperazine dihydrochloride in a new granular formulation (Ascarex D) against naturally occurring infections with Ascaris suum, Oesophagostomum dentatum and O quadrispinulatum. " 06/28/1963 - "THE EFFICACY OF TRICHLOROPHENOL PIPERAZINE AGAINST MIXED INFECTIONS OF ANCYLOSTOMA DUODENALE AND NECATOR AMERICANUS, AND ASCARIS LUMBRICOIDES." 07/01/2003 - "In the present study, one of these compounds, 7-O-[4-methyl piperazine-1-(2-acetyl)]-2H-1-benzopyran-2-one (2), which has shown promising macrofilaricidal action against rodent filariid Litomosoides carinii in cotton rats, was evaluated against infection with Brugia malayi in Mastomys coucha and jird (Meriones unguiculatus). " 10/01/1966 - "[Trial of a mixture of piperazine and pryvinium in the treatment of ascaris and oxyuris infections]." 11/17/1956 - "Whipworm infections trial of four piperazine compounds."
2.	Alzheimer Disease (Alzheimer's Disease) 02/01/2009 - "Synthesis and enzymatic evaluation of new series of N(4)-substituted piperazine naphthamide derivatives as BACE-1 inhibitors for the treatment of Alzheimer's disease are reported." 08/01/2006 - "Synthesis and efficacy of 1-[bis(4-fluorophenyl)-methyl]piperazine derivatives for acetylcholinesterase inhibition, as a stimulant of central cholinergic neurotransmission in Alzheimer's disease." 03/01/2015 - "Synthesis, biological evaluation and molecular docking study of novel piperidine and piperazine derivatives as multi-targeted agents to treat Alzheimer's disease." 01/01/2012 - "In this study, benzothiazole-piperazine compounds were synthesized by condensing the functional groups of donepezil (DNP), FK-960, and sabeluzole, which are known to have therapeutic potential against Alzheimer's disease, with the aim of obtaining new and potent anti-Alzheimer agents. "
3.	Tuberculosis (Tuberculoses) 11/01/2001 - "The N1-p-hydroxylphenyl substituted compound 22 and the methoxyphenyl substituted compound missing the piperazine ring 12 were identified as promising candidates for the further development of an improved treatment of tuberculosis. " 11/01/2009 - "Both isoprenyl PCU tetra-amine derivatives and N-decyl piperazine PCU (9a) were highly active against the XDR 194 strain of tuberculosis with MICs in the range of 0.63-3.02 microM. " 01/01/2007 - "Hydrophilic cyclic secondary amines were substituted to the core scaffold and a benzyl piperazine substitution was found to be most effective in achieving improved solubility and potent anti-tuberculosis activity. " 09/01/2014 - "In search of potential therapeutics for tuberculosis, we describe here the synthesis and in vitro antitubercular activity of a novel series of thiazolone piperazine tetrazole derivatives. "
4.	Ascariasis 03/31/1962 - "An improved piperazine preparation in the treatment of ascariasis." 07/01/1982 - "Piperazine administration decreased the prevalence of ascariasis to 33.8% at the end of the study but growth remained unaltered. " 02/01/1966 - "Field trials with piperazine derivatives against ascariasis in pigs and calves." 10/01/2006 - "Piperazine (diethylenediamine) is an anthelmintic widely used against animal and bird ascariasis. " 12/01/1973 - "[Technical piperazine hexahydrate in ascariasis of chickens]."
5.	Memory Disorders (Memory Loss) 02/16/2001 - "We have demonstrated that FK960 [N-(4-acetyl-1-piperazinyl)-p-fluorobenzamide monohydrate], a novel putative anti-dementia drug of piperazine derivative, ameliorates memory deficits in a variety of animal models of dementia in rats and monkeys, and also augments long-term potentiation (LTP) in the mossy fiber-CA3 pathway in guinea-pig hippocampal slices. " 06/01/1998 - "Our previous studies have demonstrated that FK960 (FR59960; N-(4-acetyl-1-piperazinyl)-p-fluorobenzamide monohydrate), a novel antidementia piperazine derivative, exerts beneficial effects on memory deficits in various animal models of amnesia in rats [M. " 03/01/1997 - "Our previous studies demonstrated that FK960 [N-(4-acetyl-1-piperazinyl)-p-fluorobenzamide monohydrate], a novel antidementia piperazine derivative, exerts beneficial effects on memory deficits in various rodent models of amnesia, through activation of the somatostatin neuronal system. "

Related Drugs and Biologics

1.	N-(4-acetyl-1-piperazinyl) -4-fluorobenzamide monohydrate
2.	piperazine
3.	Pyrantel
4.	Levamisole (Decaris)
5.	Mebendazole (Vermin)
6.	AJ 3941
7.	benzothiazole
8.	Dopamine Agonists (Dopamine Agonist)
9.	Tablets
10.	Excipients (Suspending Agents)

Related Therapies and Procedures

1.	Chinese Traditional Medicine (Traditional Chinese Medicine)
2.	Hormone Replacement Therapy (Therapy, Hormone Replacement)
3.	Analgesia
4.	Drug Therapy (Chemotherapy)
5.	Therapeutics