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deoxyhypusine

Also Known As:

N(6)-(4-aminobutyl)lysine; L-Lysine, N6-(4-aminobutyl)-

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675

Experts

1.	Benelli, Dario: 1 article (06/2020)
2.	Catalanotto, Caterina: 1 article (06/2020)
3.	La Teana, Anna: 1 article (06/2020)
4.	Londei, Paola: 1 article (06/2020)
5.	Martella, Marianna: 1 article (06/2020)
6.	Talora, Claudio: 1 article (06/2020)

Related Diseases

1.	Colonic Neoplasms (Colon Cancer) 06/27/2020 - "Our results show that treatment of HCT-116 colon cancer cells with the deoxyhypusine (DHS) inhibitor N1-guanyl-1,7-diamineheptane (GC7) caused both inhibition of eIF5A hypusination and a significant reduction of p53 expression in UV-treated cells, and that eIF5A controls p53 expression at the level of protein synthesis. "
2.	Neoplasms (Cancer) 08/02/1996 - "Because deoxyhypusine/hypusine formation is one of the most specific polyamine-dependent biochemical events, we decided to use N1-guanyl-1,7-diaminoheptane (GC7), a potent inhibitor for deoxyhypusine synthase, to assess the role of hypusine formation on tumor growth and differentiation. "
3.	Hypertension (High Blood Pressure) 03/01/1984 - "Hydralazine, one of the most frequently prescribed drugs for the treatment of moderate to severe hypertension, added to the culture, resulted in the accumulation of a protein(s) containing the precursor amino acid deoxyhypusine [N epsilon-(4-aminobutyl)lysine]. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Protein S
3.	Polyamines
4.	Lysine (L-Lysine)
5.	Hydralazine (Apresoline)
6.	Amino Acids
7.	hypusine
8.	deoxyhypusine synthase