medullasin

10/01/2000 - "Eighty-five out of 112 patients with multiple sclerosis (75.8%) showed positive results (above means of normals + 2 SD) in the medullasin test, while 15.4% (12/78) of patients with non-inflammatory neurological disease had positive results. "
03/01/2002 - "[Determination of medullasin levels for the diagnosis of multiple sclerosis]."
10/01/2000 - "Determination of medullasin levels for the diagnosis of multiple sclerosis."
12/15/1988 - "Granulocytes obtained from patients with multiple sclerosis in active phase and those from patients with Behçet's disease in relapse showed elevated levels of medullasin as compared with normal controls. "
03/01/1984 - "Measurement of medullasin activity in mature granulocytes may become useful in both diagnosis and evaluation of multiple sclerosis."

10/01/1998 - "These findings suggest that medullasin may be involved in host defence and immunoregulation in a NF-induced rat model of gingival overgrowth."
07/01/2002 - "An involvement of granulocyte medullasin in phenytoin-induced gingival overgrowth in rats."
10/01/1998 - "Role of medullasin in nifedipine-induced gingival overgrowth in rats."
01/01/1996 - "Possible roles of medullasin in nifedipine-induced human gingival overgrowth."
01/01/1996 - "Further, medullasin-positive cells of zones II and III in the overgrowth group had infiltrated more extensively than those in the gingivitis group (p < 0.001), indicating the participation of this enzyme in the mechanism of NF-induced gingival overgrowth. "

11/01/1990 - "Large amounts of medullasin were also detected in GCF from experimental gingivitis subjects, although it was not detected by the activity measurements. "
11/01/1990 - "Granulocyte medullasin levels in gingival crevicular fluid from chronic adult periodontitis patients and experimental gingivitis subjects."
01/01/1996 - "Further, medullasin-positive cells of zones II and III in the overgrowth group had infiltrated more extensively than those in the gingivitis group (p < 0.001), indicating the participation of this enzyme in the mechanism of NF-induced gingival overgrowth. "
05/01/1995 - "Levels of lysosomal proteinases such as cathepsins B, H, L, G and medullasin were determined in gingival crevicular fluid from periodontitis patients and experimental gingivitis subjects by activity measurement and sensitive immunoassay. "
11/01/1990 - "The concentration of medullasin, an elastase-like serine proteinase, in gingival crevicular fluid (GCF) from chronic adult periodontitis patients and experimental gingivitis subjects was determined by the highly sensitive immunoassay method. "

11/01/1990 - "In periodontitis patients, the medullasin content increased with increase of the GCF volume and then attained a maximum value at a relatively mildly inflamed stage. "
11/01/1990 - "There was a rapid increase in the medullasin content during the 4-day period after abstention from oral hygiene measures, which corresponded to those of severely inflamed periodontitis patients. "
05/01/1995 - "Levels of lysosomal proteinases such as cathepsins B, H, L, G and medullasin were determined in gingival crevicular fluid from periodontitis patients and experimental gingivitis subjects by activity measurement and sensitive immunoassay. "

11/01/1990 - "The results suggest that medullasin plays important roles both in the defence mechanism against the gingival inflammation and in the development of the acute inflammation."
08/01/1983 - "These results indicate that medullasin in granulocytes plays an important role in the development of inflammation."
08/01/1983 - "Role of medullasin in granulocytes in the development of inflammation. "
08/01/1983 - "Injection of a small amount of medullasin protease (20 micrograms) into the skin of guinea pigs or rabbits caused inflammation characterized by severe injury to endothelial cells in venules and by infiltration of a large number of macrophages. "