3'- (4- morpholinyl)- 3'- deaminodaunorubicin

RN given refers to parent cpd(8S-cis)-isomer; structure given in first source

Also Known As:

3'-(4-morpholinyl)-3'-deaminodaunorubicin hydrobromide, (8S-cis)-isomer; MDADR; morpholinodaunomycin; 5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-((2,3,6-trideoxy-3-(4-morpholinyl)-alpha-L-lyxo-hexopyranosyl)oxy)-, (8S-cis)-

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Carcinoma (Carcinomatosis) 03/01/1983 - "Pharmacological studies of 3'-(4-morpholinyl)-3'-deaminodaunorubicin in human colon carcinoma cells in vitro." 11/01/1986 - "The sugar amine modified anthracyclines, 3'-(4-morpholinyl)-3'-deaminodaunorubicin (MD) and 3'-(4-methoxy-1-piperidinyl)-3'-deaminodaunorubicin (MEO), are 10-fold more potent than daunorubicin (DAU) as inhibitors of RNA synthesis in human colon carcinoma (HT-29) cells in vitro, although they are 10-fold less cytocidal. "
2.	Neoplasms (Cancer) 03/01/1987 - "Induction of malignant transformation in vitro and mammary tumors in rats by two new potent anthracycline antitumor antibiotics, morpholinodaunomycin and cyanomorpholinoadriamycin."
3.	Chromosome Aberrations (Chromosome Abnormalities) 01/01/1985 - "Formation of DNA-adducts and induction of DNA-crosslinks and chromosomal aberrations by the new potent anthracycline antitumor antibiotics: morpholinodaunomycin, cyanomorpholinodaunomycin and cyanomorpholinoadriamycin."

Related Drugs and Biologics

1.	Anthracyclines
2.	Anti-Bacterial Agents (Antibiotics)
3.	3'- deamino- 3'- (3- cyano- 4- morpholinyl)doxorubicin
4.	DNA Adducts
5.	RNA (Ribonucleic Acid)
6.	DNA (Deoxyribonucleic Acid)
7.	Daunorubicin (Cerubidine)
8.	Amines
9.	Sugars
10.	cyanomorpholinodaunomycin