methyl 6,7- dimethoxy- 4- ethyl- beta- carboline- 3- carboxylate

10/05/2014 - "This raises the possibility that DMCM may be particularly effective at evoking forebrain seizures, which is a challenge in neonatal animals due to the relative immaturity of the forebrain seizure network. "
05/01/1988 - "In vivo studies show that DMCM, Ia, Ib, IIa and IIb elicit three dose-dependent stages of electrocortical changes (trains of slow waves, trains of spike-and-wave complexes and "grand-mal" seizures). "
11/15/2014 - "PB protected against DMCM-evoked seizures when administered in doses of 5mg/kg or greater. "
11/15/2014 - "TGB protected against DMCM-evoked seizures when administered in doses of 1mg/kg or greater. "
11/15/2014 - "We found that LEV significantly protected against DMCM seizures when administered in doses of 10mg/kg and greater. "

01/01/2001 - "The present study was designed to test the impact of relatively low doses of DMCM on multiple measures of pain reactivity and learning. "
01/01/2001 - "It is suggested that DMCM induces a state of panic and that this state inhibits pain."
01/01/2001 - "Experiment 1 showed that DMCM inhibits both a spinal nociceptive reflex (tail-flick to heat) and a supraspinal measure of pain (vocalization to shock). "
01/01/2001 - "The anxiogenic DMCM, an inverse benzodiazepine agonist, was used to explore the relationship between negative affective states and pain. "
01/01/2001 - "Pain and negative affect: evidence the inverse benzodiazepine agonist DMCM inhibits pain and learning in rats."

01/01/2023 - "Differential gene expression is associated with diabetic cardiomyopathy (DMCM) and culminates in adverse remodeling in the diabetic heart. "
01/01/2020 - "Diabetic cardiomyopathy (DMCM) is the leading cause of mortality and morbidity among diabetic patients. "
01/01/2021 - "DM increases the risk of heart failure by diabetic cardiomyopathy (DMCM), a cardiac muscle disorder that leads to a progressive decline in diastolic function, and ultimately systolic dysfunction. "
01/01/2020 - "Early pathogenesis of diabetic cardiomyopathy (DMCM) may involve lipotoxicity of cardiomyocytes in the context of hyperglycemia. "
12/11/2019 - "Obesity increases the risk of developing diabetes and subsequently, diabetic cardiomyopathy (DMCM). "

01/01/2021 - "HF exists along a spectrum from stage A (ie, persons at risk of DM) to stage D (ie, refractory HF from end-stage DM cardiomyopathy [DMCM]). "
09/01/2020 - "The signaling pathways associated with diabetic mellitus cardiomyopathy (DMCM) were investigated using a rat model. "
01/01/2019 - "This review focuses on H2S in the signaling of apoptotic, autophagic, necroptotic, and pyroptotic cell death in DMCM and other cardiomyopathies, abnormalities in H2S synthesis in DM, and potential H2S-based therapeutic strategies to mitigate myocardial cell death to ameliorate DMCM."
11/02/2017 - "Current treatments focus on macro-revascularization and neglect the microvascular disease typical of diabetes mellitus-induced cardiomyopathy (DMCM). "
01/01/2019 - "Understanding the roles of the cell death signaling pathways involved in the development of cardiomyopathies is crucial to the discovery of novel targeted therapeutics and biomarkers for DMCM. "

07/01/1992 - "The suppression of punished and nonpunished responding by CRF and DMCM was mimicked by increasing the shock intensity (delta = 0.1 to 0.6 mA) during the punishment component. "
01/01/2001 - "In experiment 1, systemic injections of 0.00, 0.015, 0.06, and 0.25 mg/kg DMCM were administered before vocalization and tail movements were assessed in response to a gradually incremented shock and radiant heat stimulus. "
01/01/2001 - "Experiment 1 showed that DMCM inhibits both a spinal nociceptive reflex (tail-flick to heat) and a supraspinal measure of pain (vocalization to shock). "
07/01/1998 - "Furthermore, the anxiogenic methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM) (0.3 mg/kg i.p.), which produces effects similar to those produced by inescapable shock, also potentiated morphine place preference. "
08/01/1995 - "Microinjection of the inverse agonist Methyl 6,7-Dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM) in the region of the DRN produced enhancement of fear conditioning as assessed by the amount of freezing in the presence of shock cues as well as interference with shuttlebox escape learning assessed 24 hr later. "