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mitochondrial calcium uniporter

highly active ruthenium red-sensitive uniporter
Also Known As:
MCU protein; calcium uniporter
Networked: 119 relevant articles (3 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Rizzuto, Rosario: 5 articles (01/2021 - 01/2013)
2. Wang, Shilei: 5 articles (01/2016 - 04/2013)
3. Pinton, Paolo: 4 articles (01/2020 - 01/2013)
4. Ge, Junbo: 3 articles (12/2021 - 11/2018)
5. Nichols, Matthew: 3 articles (11/2020 - 01/2018)
6. Robertson, George S: 3 articles (11/2020 - 01/2018)
7. Mammucari, Cristina: 3 articles (12/2019 - 01/2016)
8. Li, Minghui: 3 articles (11/2019 - 11/2018)
9. Yu, Yong: 3 articles (11/2019 - 11/2018)
10. Bertolini, Mayara S: 3 articles (01/2019 - 01/2017)

Related Diseases

1. Neuroinflammatory Diseases
2. Infarction (Infarctions)
3. Alzheimer Disease (Alzheimer's Disease)
10/25/2022 - "[Mitochondrial calcium uniporter knockdown in hippocampal neurons improved the learning and memory dysfunction of Alzheimer's disease mice]."
04/01/2020 - "Mitochondrial calcium uniporter as a potential therapeutic strategy for Alzheimer's disease."
10/25/2022 - "Alzheimer's disease (AD) is a progressive and degenerative disorder accompanied by cognitive decline, which could be promoted by mitochondrial dysfunction induced by mitochondrial Ca 2+ (mCa 2+) homeostasis Mitochondrial calcium uniporter (MCU), a key channel of mCa 2+ uptake, may be a target for AD treatment. "
01/01/2021 - "Synergistic enhancing-memory effect of D-serine and RU360, a mitochondrial calcium uniporter blocker in rat model of Alzheimer's disease."
12/01/2019 - ": Aβ: amyloid β; AD: Alzheimer disease; ACTB: actin beta; AMPK: AMP-activated protein kinase; APP: amyloid-beta precursor protein; BafA: bafilomycin A1; BAPTA-AM: 1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid acetoxymethyl ester; CFP: cyan fluorescent protein; EGTA-AM: ethylene glycol-bis(β-aminoethyl ether)-N,N,N',N'-tetraacetic acid acetoxymethyl ester; ER: endoplasmic reticulum; EGFP-HDQ74: enhanced GFP-huntingtin exon 1 containing 74 polyglutamine repeats; FAD: familial Alzheimer disease; FCS: fetal calf serum; FRET: fluorescence/Förster resonance energy transfer; GFP: green fluorescent protein; IP3: inositol trisphosphate; KD: knockdown; LAMP1: lysosomal associated membrane protein 1; MAP1LC3-II/LC3-II: lipidated microtubule-associated protein 1 light chain 3; MCU: mitochondrial calcium uniporter; MICU1: mitochondrial calcium uptake 1; MEFs: mouse embryonic fibroblasts; MFN2: mitofusin 2; MTOR: mechanistic target of rapamycin kinase; MTORC1: MTOR complex 1; SQSTM1/p62: sequestosome 1; PSEN1: presenilin 1; PSEN2: presenilin 2; RAB7: RAB7A: member RAS oncogene family; RFP: red fluorescent protein; ATP2A/SERCA: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting; siRNA: small interference RNA; V-ATPase: vacuolar-type H+-ATPase; WT: wild type."
4. Postoperative Cognitive Complications
5. Heart Failure

Related Drugs and Biologics

1. Ru 360
2. L-Lactate Dehydrogenase (Lactate Dehydrogenase)
3. Dynamins (Dynamin)
4. Ruthenium Red
5. Aconitine
6. isoborneol (borneol)
7. Calcium
8. Spermine
9. Iron
10. Oxygen (Dioxygen)