polymeric IgA

01/01/1983 - "These results suggest that a defect in the hepatic clearance of circulating polymeric IgA-IC exists in patients with IgA nephropathy."
08/01/1982 - "A study on the detection of polymeric IgA in glomeruli from renal biopsy specimens in patients with IgA nephropathy is described. "
10/01/2015 - "IgA nephropathy (IgAN) is the finding of immune deposits predominantly containing polymeric IgA in the glomerular mesangium on renal biopsy. "
01/01/2011 - "The hallmark of IgA nephropathy (IgAN) is the mesangial deposits of polymeric IgA. "
09/01/2007 - "IgA nephropathy (IgAN) is characterized by mesangial deposition of polymeric IgA (pIgA). "

04/01/1983 - "Dual role of the liver in regulating circulating polymeric IgA in man: studies on patients with liver disease."
04/01/1983 - "Failure of either clearance mechanism due to liver disease results in elevated serum polymeric IgA levels. "
01/01/2008 - "The proportion of dimeric/polymeric IgA increases in a number of important diseases, such as IgA nephropathy and in chronic liver disease. "
06/01/1989 - "These findings suggest that J chain-linked polymeric IgA bound to the surface of hepatocytes and Kupffer cells has a certain pathological significance in liver diseases and might be involved in the clearance of excess IgA from the circulation."
01/01/1985 - "Studies are surveyed which indicate that, although this process occurs in man, it is to a strikingly lesser degree, and interruption of this pathway does not explain the high serum IgA levels often seen in chronic liver disease: the explanation for this lies in enhanced synthesis of IgA, and diminished polymeric IgA catabolism unrelated to hepatobiliary transport."

03/20/1992 - "In the human HT-29 epithelial cell line, polymeric IgA (pIgA) specific for EBV promoted infection of the otherwise refractory epithelial cells. "
02/01/1992 - "[Detection of polymeric IgA antibody to herpes simplex virus by pretreatment of sera with Streptococcus pyogenes--its application to diagnosis of primary infection]."
01/01/2006 - "PR8 (H1N1) influenza virus injected into the ovarian bursa of BALB/c mice grew well, with peak titers between days 3 and 5. Intravenous injection of polymeric IgA anti-influenza virus monoclonal antibody before or 30 min after viral challenge protected mice against viral infection. "
05/25/2000 - "J-chain-deficient (Jch(-/-)) mice were used to study the role of polymeric IgA (pIgA) in primary disease and protective immunity following genital herpes simplex type 2 (HSV-2) infection. "
08/01/1994 - "Viral DNA was found in concert with one serologic marker of acute infection, EBV-specific polymeric IgA, that could affect patterns of viral spread and clinical symptomatology."

01/01/2007 - "It has been assumed that removal of tonsillar tissues might reduce the production of polymeric IgA and decrease the frequency of renal parenchymal damage resulting from episodes of macroscopic hematuria and proteinuria. "
04/10/1981 - "Such bad evolution might be predicted by the existence of arterial hypertension, severe proteinuria, degree of glomerular sclerosis, presence of HLA Bw35, and increased polymeric IgA in serum. "
01/01/1988 - "Postoperatively, proteinuria disappeared in 9 cases and improved in 3 and the levels of serum IgA, the circulating immune complex (CIC) and serum polymeric IgA decreased. "

05/01/1990 - "Jejunal secretion of polymeric IgA and the density of IgA-containing plasma cells in the lamina propria were significantly lower in patients with Crohn's disease than in both control groups. "
04/01/1992 - "The intestinal clearance of alpha 1-antiproteinase, monomeric IgA and IgG, and the daily fecal output of polymeric IgA and IgM were investigated in patients with inflammatory bowel diseases (inactive and active Crohn's disease, ulcerative colitis) and in a control group. "