HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

glycyl-prolyl-arginyl-proline

synthetic peptide which prevents polymerization of fibrin molecules; a fibrin A-knob mimetic

Also Known As:

GPRP peptide; Gly-Pro-Arg-Pro

Networked: 11 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - glycyl-prolyl-arginyl-proline: 11

Experts

1.	Ekholt, Karin: 1 article (01/2022)
2.	Espevik, Terje: 1 article (01/2022)
3.	Johnson, Christina: 1 article (01/2022)
4.	Lau, Corinna: 1 article (01/2022)
5.	Mollnes, Tom Eirik: 1 article (01/2022)
6.	Nilsson, Per H: 1 article (01/2022)
7.	Pischke, Søren Erik: 1 article (01/2022)
8.	Quach, Huy Quang: 1 article (01/2022)
9.	Woodruff, Trent M: 1 article (01/2022)
10.	Chen, Honglv: 1 article (01/2021)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2022 - "In this study, we exploited the anticoagulant peptide Gly-Pro-Arg-Pro (GPRP) that blocks fibrin polymerization to study the effects of thrombin on acute inflammation in response to Escherichia coli and Staphylococcus aureus Human blood was anticoagulated with either GPRP or the thrombin inhibitor lepirudin and incubated with either E. "
2.	Thrombosis (Thrombus) 07/01/2016 - "To further develop μPlg into a thrombolytic agent with anti-thrombus properties, we constructed two μPlg variants containing tripeptide Arg-Gly-Asp (RGD) and tetrapeptide Gly-Pro-Arg-Pro (GPRP) by site-directed mutagenesis. " 09/28/2013 - "Furthermore, a fibrin-specific magnetic resonance imaging (MRI) contrast agent was successfully prepared by connecting the composite spheres with pentapeptide Gly-Pro-Arg-Pro-Pro, which can significantly increase the MRI signal of thrombus." 11/01/1990 - "Similar although lesser effects were observed by reducing thrombin synthesis with antibodies to factors II and X. To decouple the role of thrombin in platelet recruitment by direct stimulation of platelet activity from its role in thrombus stabilization via fibrin formation, thrombosis was measured in heparinized blood treated with the tetrapeptide glycyl-prolyl-arginyl-proline, which inhibits fibrin monomer assembly into fibrin. "
3.	Venous Thromboembolism 01/01/2006 - "A pentapeptide, Gly-Pro-Arg-Pro-Pro, with high affinity for alpha-chain-fibrin was labeled with (99m)Tc ((99m)Tc-TP850) and evaluated in swine to image experimental venous thromboembolism (deep vein thrombosis [DVT]) and pulmonary embolism (PE). "
4.	Venous Thrombosis (Deep-Vein Thrombosis) 01/01/2006 - "A pentapeptide, Gly-Pro-Arg-Pro-Pro, with high affinity for alpha-chain-fibrin was labeled with (99m)Tc ((99m)Tc-TP850) and evaluated in swine to image experimental venous thromboembolism (deep vein thrombosis [DVT]) and pulmonary embolism (PE). "
5.	Wounds and Injuries (Trauma) 05/01/1994 - "Platelet activation was studied in normal volunteers by whole blood flow cytometric analysis of modulation of platelet surface GMP-140 and the glycoprotein (GP) Ib-IX complex in: a) shed blood emerging from a standardized in vivo bleeding time wound; b) peripheral blood activated in vitro with either thrombin (in the presence of gly-pro-arg-pro, an inhibitor of fibrin polymerization) or the stable thromboxane (TX) A2 analogue U46619. "

Related Drugs and Biologics

1.	Fibrin
2.	Thrombin
3.	Peptides (Polypeptides)
4.	Anticoagulants
5.	lepirudin (Refludan)
6.	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
7.	P-Selectin
8.	Cytokines
9.	Urokinase-Type Plasminogen Activator (Urokinase)
10.	Thromboxanes

Related Therapies and Procedures

1.	Intranasal Administration