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eboracin
specifically inhibits tonic component of metrazol seizures in mice; structure
Also Known As:
methyl 1,3a,4,8a-tetrahydro-3a,8b-dihydroxy-2-methyl-4-oxoindeno(1,2b)pyrrole-3-carboxylate; Indeno(1,2-b)pyrrole-3-carboxylic acid, 1,3a,4,8b-tetrahydro-3a,8b-dihydroxy-2-methyl-4-oxo-, methyl ester
Networked:
5
relevant articles (
2
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Polycyclic Aromatic Hydrocarbons: 2020
Indenes: 4
eboracin: 5
Polycyclic Compounds: 6
Polycyclic Aromatic Hydrocarbons: 2020
Indenes: 4
eboracin: 5
Related Diseases
1.
Seizures (Absence Seizure)
04/01/1982 - "
Effect of eboracin on convulsive seizures in mice: enhancement of myoclonus and inhibition of the tonic phase.
"
04/01/1982 - "
Single doses decreased the incidence of tonic-clonic seizures (ED50=28-35 mg/kg); complete inhibition of tonus followed doses of 40-150 mg/kg. A dose of 75-150 mg/kg of eboracin prolonged the duration and increased the severity of the myoclonic component of seizures induced by pentylenetetrazol.
"
07/01/1985 - "
Conversely, the indenopyrrole, eboracin, protected mice from seizures induced by auditory stimulation and altered the response to Metrazol.
"
04/01/1982 - "
Eboracin, a substituted trioxyindenopyrrole, inhibited the tonic component of convulsive seizures induced in mice by pentylenetetrazol, electroshock or auditory stimulation.
"
01/01/1982 - "
Eboracin: a substituted indenopyrrole active against metrazol-induced, audiogenic and electroshock seizures in mice.
"
2.
Status Epilepticus (Complex Partial Status Epilepticus)
01/01/1985 - "
Intermediate doses of either agent led to a form of clonic status epilepticus which persisted for an average of 18 min in phenytoin-treated and 58 min in eboracin-treated mice.
"
3.
Myoclonus (Nocturnal Myoclonus)
04/01/1982 - "
Effect of eboracin on convulsive seizures in mice: enhancement of myoclonus and inhibition of the tonic phase.
"
4.
Hyperkinesis
05/01/1986 - "
The hyperkinesia could be controlled by dimethylaminoethanol, phenobarbital and by an experimental anticonvulsive agent, eboracin.
"
Related Drugs and Biologics
1.
Pentylenetetrazole (Metrazol)
2.
Phenytoin (Dilantin)
3.
Oxidopamine (6 Hydroxydopamine)
4.
Phenobarbital (Luminal)
5.
Esters
6.
Deanol (Dimethylethanolamine)
7.
Anticonvulsants (Antiepileptic Drugs)