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3,7,11,15- tetramethyl- 2,4,6,10,14- hexadecapentaenoic acid

Subscribe to New Research on 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid

has strong binding affinity to cellular retinoic acid-binding protein; RN given refers to (trans)-isomer; structure given in first source

Also Known As:

3,7,11,15-tetramethyl-trans-2,4,6,10,14-hexadecapentaenoic acid; E 5166; E5166; TMHDP; acyclic retinoid; polyprenoic acid; 2,4,6,10,14-Hexadecapentaenoic acid, 3,7,11,15-tetramethyl-, (all-E)-

Networked: 80 relevant articles (8 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Moriwaki, Hisataka: 23 articles (06/2015 - 05/2002)
2.	Shimizu, Masahito: 16 articles (01/2014 - 02/2004)
3.	Kojima, Soichi: 10 articles (01/2013 - 01/2002)
4.	Okuno, Masataka: 9 articles (01/2011 - 01/2002)
5.	Shirakami, Yohei: 8 articles (01/2014 - 01/2009)
6.	Tsurumi, Hisashi: 7 articles (01/2013 - 05/2004)
7.	Matsushima-Nishiwaki, Rie: 7 articles (03/2007 - 01/2002)
8.	Takai, Koji: 6 articles (01/2014 - 01/2002)
9.	Shidoji, Yoshihiro: 6 articles (02/2013 - 05/2002)
10.	Ishibashi, Naoto: 6 articles (01/2013 - 05/2007)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 01/01/2013 - "The acyclic retinoid, peretinoin, has been shown to be effective for suppressing hepatocellular carcinoma (HCC) recurrence after definitive treatment in a small-scale randomized clinical trial. " 06/01/2015 - "This study examined the effects of peretinoin, an acyclic retinoid, on the survival of patients with hepatitis C virus-related hepatocellular carcinoma (HCC) who had completed curative therapy and participated in a randomized, placebo-controlled trial. " 06/01/2015 - "Survey of survival among patients with hepatitis C virus-related hepatocellular carcinoma treated with peretinoin, an acyclic retinoid, after the completion of a randomized, placebo-controlled trial." 01/01/2015 - "In this study, we demonstrated that acyclic retinoid (ACR) induced nuclear accumulation of TG2 in JHH-7 cells, a hepatocellular carcinoma (HCC) leading to their apoptosis. " 01/01/2014 - "Clinical studies suggest that the oral acyclic retinoid Peretinoin may reduce the recurrence of hepatocellular carcinoma (HCC) following surgical ablation of primary tumours. "
2.	Neoplasms (Cancer) 04/01/2012 - "The effects of acyclic retinoid, lipiodol-iodine-131 and tumor vaccine treatment were promising but require further study. " 04/01/2012 - "Postoperative therapies involving acyclic retinoid, lipidol-iodine-131, or tumor vaccine may improve the OS of patients with HCC after curative treatment." 01/01/2012 - "Acyclic retinoid (ACR), a synthetic retinoid, successfully improves HCC patient survival by preventing recurrence and the formation of secondary tumors. " 08/01/2010 - "Chemopreventive anti-cancer agent acyclic retinoid suppresses allogeneic immune responses in rats." 05/01/2007 - "An antioxidant effect by acyclic retinoid suppresses liver tumor in mice."
3.	Acute Promyelocytic Leukemia 11/01/1996 - "We investigated the in vitro efficacy of acyclic retinoid to induce the differentiation of acute promyelocytic leukemia (APL) cells using primary cultured cells obtained from 11 APL patients. " 11/01/1996 - "Differentiation effect of acyclic retinoid on acute promyelocytic leukemia cells." 05/01/2004 - "We particularly focus upon the therapeutic application of all-trans RA (atRA) to acute promyelocytic leukemia (APL) and on the preventive approach to hepatocellular carcinoma (HCC) by a synthetic retinoid analog, acyclic retinoid. " 12/01/1993 - "We studied the in vitro efficacy of acyclic retinoid for the differentiation induction of human promyelocyte-derived HL-60 cell line and primary cultured blast cells obtained from 8 patients with acute non-lymphocytic leukemia (ANLL) including 3 acute promyelocytic leukemia (APL) patients. "
4.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 12/01/1993 - "We studied the in vitro efficacy of acyclic retinoid for the differentiation induction of human promyelocyte-derived HL-60 cell line and primary cultured blast cells obtained from 8 patients with acute non-lymphocytic leukemia (ANLL) including 3 acute promyelocytic leukemia (APL) patients. " 11/01/1996 - "Acyclic retinoid (all-trans-3, 7, 11, 15-tetramethyl-2, 4, 6, 10, 14-hexadecapentaenoic acid) binds cellular retinoic acid-binding protein with an affinity similar to that of all-trans retinoic acid and induces differentiation of human hepatoma cell lines and a human acute myelogenous leukemia cell line (HL-60). "
5.	Lymphoid Leukemia 12/01/1993 - "We studied the in vitro efficacy of acyclic retinoid for the differentiation induction of human promyelocyte-derived HL-60 cell line and primary cultured blast cells obtained from 8 patients with acute non-lymphocytic leukemia (ANLL) including 3 acute promyelocytic leukemia (APL) patients. "

Related Drugs and Biologics

1.	3,7,11,15- tetramethyl- 2,4,6,10,14- hexadecapentaenoic acid
2.	Tamoxifen
3.	Vitamin A (Retinol)
4.	(5- fluoro- 2- methyl- 1- (4- pyridyl)methylene- 3- (N- benzyl)- indene)- acetamide hydrochloride
5.	Isotretinoin (Accutane)
6.	Vitamins
7.	Inositol (Myoinositol)
8.	Carotenoids (Carotene)
9.	retinol palmitate (retinyl palmitate)
10.	geranylgeranic acid

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Chemoprevention
3.	Oral Administration
4.	Heterologous Transplantation (Xenotransplantation)
5.	Hepatectomy